BDBM188516 BDOIA383

SMILES COc1ccc(CCc2nc3cc(ccc3n2CCN2CCOCC2)-c2c(C)noc2C)cc1

InChI Key InChIKey=RQFUKBAHMUVXDA-UHFFFAOYSA-N

Data  4 IC50  2 Kd

PDB links: 3 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 188516   

TargetCREB-binding protein(Homo sapiens (Human))
Pfizer

LigandPNGBDBM188516(BDOIA383)
Affinity DataIC50:  120nMAssay Description:The assay used His-tagged CBP protein, biotinylated histone H4, and detection reagents europium-labeled streptavidin and anti-6His antibody labeled w...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Pfizer

LigandPNGBDBM188516(BDOIA383)
Affinity DataIC50:  2.40E+3nMAssay Description:The assay used a Cy5 dye-labeled BRD inhibitor PFI-411FP. The synthesis of the probe and the procedure for the assay was reported recently (Hett et a...More data for this Ligand-Target Pair
TargetCREB-binding protein(Homo sapiens (Human))
Pfizer

LigandPNGBDBM188516(BDOIA383)
Affinity DataIC50:  120nMAssay Description:Inhibition of CREBBP (unknown origin) by FRET assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Pfizer

LigandPNGBDBM188516(BDOIA383)
Affinity DataKd:  780nMAssay Description:Experiments were performed using recombinant CBP and BRD4 bromodomainsusing the procedure reported recently (Hett et al., 2015).More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Pfizer

LigandPNGBDBM188516(BDOIA383)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of BRD4 (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetCREB-binding protein(Homo sapiens (Human))
Pfizer

LigandPNGBDBM188516(BDOIA383)
Affinity DataKd:  120nMAssay Description:Experiments were performed using recombinant CBP and BRD4 bromodomainsusing the procedure reported recently (Hett et al., 2015).More data for this Ligand-Target Pair