BDBM19151 (1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-bis(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone::Antibiotic FR 901228::CHEMBL343448::Depsipeptide::FK228::Romidepsin
SMILES C\C=C1/NC(=O)[C@H]2CSSCC\C=C\[C@H](CC(=O)N[C@H](C(C)C)C(=O)N2)OC(=O)[C@@H](NC1=O)C(C)C
InChI Key InChIKey=OHRURASPPZQGQM-GCCNXGTGSA-N
Data 15 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 19151
Affinity DataIC50: 787nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Sichuan University And Collaborative Innovation Center
Curated by ChEMBL
Affinity DataIC50: 36nMAssay Description:Inhibition of C-terminal biotin-labelled BCoR/wild-type BCL6 BTB domain (unknown origin) protein-protein interaction by ELISAMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Graduate School Of Life Science And Systems Engineering
Curated by ChEMBL
Graduate School Of Life Science And Systems Engineering
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of HDAC1 by fluorimetric assay in presence of DTTMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Graduate School Of Life Science And Systems Engineering
Curated by ChEMBL
Graduate School Of Life Science And Systems Engineering
Curated by ChEMBL
Affinity DataIC50: 36nMAssay Description:Inhibition of HDAC1 by fluorimetric assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Graduate School Of Life Science And Systems Engineering
Curated by ChEMBL
Graduate School Of Life Science And Systems Engineering
Curated by ChEMBL
Affinity DataIC50: 620nMAssay Description:Inhibition of HDAC6 by fluorimetric assay in presence of DTTMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Graduate School Of Life Science And Systems Engineering
Curated by ChEMBL
Graduate School Of Life Science And Systems Engineering
Curated by ChEMBL
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of HDAC6 by fluorimetric assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Graduate School Of Life Science And Systems Engineering
Curated by ChEMBL
Graduate School Of Life Science And Systems Engineering
Curated by ChEMBL
Affinity DataIC50: 510nMAssay Description:Inhibition of HDAC4 by fluorimetric assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)(Homo sapiens (Human))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant HDAC3/NCoR2 using Ac-Lys(Ac)-AMC as substrate after 30 mins by fluorescence analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Graduate School Of Life Science And Systems Engineering
Curated by ChEMBL
Graduate School Of Life Science And Systems Engineering
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of recombinant HDAC6 using Ac-Lys(Ac)-AMC as substrate after 30 mins by fluorescence analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant HDAC2 using Ac-Lys(Ac)-AMC as substrate after 30 mins by fluorescence analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Graduate School Of Life Science And Systems Engineering
Curated by ChEMBL
Graduate School Of Life Science And Systems Engineering
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of recombinant HDAC1 using Ac-Lys(Ac)-AMC as substrate after 30 mins by fluorescence analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Graduate School Of Life Science And Systems Engineering
Curated by ChEMBL
Graduate School Of Life Science And Systems Engineering
Curated by ChEMBL
Affinity DataIC50: 0.310nMAssay Description:Inhibition of human recombinant HDAC1 after 1 hr by luminescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
Graduate School Of Life Science And Systems Engineering
Curated by ChEMBL
Graduate School Of Life Science And Systems Engineering
Curated by ChEMBL
Affinity DataIC50: 670nMAssay Description:Inhibition of human recombinant HDAC6 after 1 hr by luminescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Graduate School Of Life Science And Systems Engineering
Curated by ChEMBL
Graduate School Of Life Science And Systems Engineering
Curated by ChEMBL
Affinity DataIC50: 8.67E+3nMAssay Description:Inhibition of human recombinant HDAC4 after 1 hr by luminescence assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Graduate School Of Life Science And Systems Engineering
Curated by ChEMBL
Graduate School Of Life Science And Systems Engineering
Curated by ChEMBL
Affinity DataIC50: 3.97nMpH: 8.0 T: 2°CAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair