BDBM197160 GNE-140 (6)

SMILES OC1=C(Sc2ccccc2Cl)C(=O)N[C@@](C1)(c1ccsc1)c1ccc(cc1)N1CCOCC1

InChI Key InChIKey=SUFXXEIVBZJOAP-RUZDIDTESA-N

Data  12 IC50  3 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 197160   

TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

LigandPNGBDBM197160(GNE-140 (6))
Affinity DataIC50:  3nMAssay Description:LDHA, LDHB, LDHC, MDH1 and MDH2 enzymatic assays have been described in detail previously [Dragovich, P.S. et al, Bioorg. Med. Chem. Lett. 24:3764-37...More data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

LigandPNGBDBM197160(GNE-140 (6))
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant carboxy-terminal His-tagged LDHA by UV endpoint assayMore data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

LigandPNGBDBM197160(GNE-140 (6))
Affinity DataEC50:  7.20nMAssay Description:Inhibition of human LDH5 using pyruvate as substrate after 10 minsMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM197160(GNE-140 (6))
Affinity DataIC50: >5.70E+4nMAssay Description:Inhibition of wild type IDH1 (unknown origin) using isocitrate as substrate preincubated for 30 mins followed by substrate addition in presence of NA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

LigandPNGBDBM197160(GNE-140 (6))
Affinity DataIC50:  424nMAssay Description:Inhibition of human liver LDHA using sodium pyruvate as substrate after 5 mins in presence of NAPDH and EDTA by diaphorase/resazurin based fluorescen...More data for this Ligand-Target Pair
TargetL-lactate dehydrogenase B chain(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM197160(GNE-140 (6))
Affinity DataIC50:  441nMAssay Description:Inhibition of human erythrocytes LDHB using sodium pyruvate as substrate after 5 mins in presence of NAPDH by diaphorase/resazurin based fluorescence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

LigandPNGBDBM197160(GNE-140 (6))
Affinity DataIC50:  1.44E+3nMAssay Description:Inhibition of human liver LDHA using sodium pyruvate as substrate after 5 mins in presence of NAPDH and EDTA by diaphorase/resazurin based fluorescen...More data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

LigandPNGBDBM197160(GNE-140 (6))
Affinity DataIC50: <10nMAssay Description:Inhibition of human liver LDHA using sodium pyruvate as substrate after 5 mins in presence of NAPDH and EDTA by diaphorase/resazurin based fluorescen...More data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

LigandPNGBDBM197160(GNE-140 (6))
Affinity DataIC50:  424nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

LigandPNGBDBM197160(GNE-140 (6))
Affinity DataIC50:  877nMAssay Description:Inhibition of LDH in human MIAPaCa2 cells assessed as reduction in lactate production preincubated for 2 hrs measured after 30 mins by high throughpu...More data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

LigandPNGBDBM197160(GNE-140 (6))
Affinity DataEC50:  1.26E+3nMAssay Description:Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...More data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

LigandPNGBDBM197160(GNE-140 (6))
Affinity DataEC50:  8.90nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged LDHA (1 to 332 residues) expressed in Escherichia coli using sodium pyruvate as sub...More data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Genentech

LigandPNGBDBM197160(GNE-140 (6))
Affinity DataIC50:  670nMAssay Description:Inhibition of LDHA in human MiPaca2 cells assessed as inhibition of lactate productionMore data for this Ligand-Target Pair
TargetL-lactate dehydrogenase B chain(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM197160(GNE-140 (6))
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant carboxy-terminal His-tagged LDHB by UV endpoint assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase B chain(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM197160(GNE-140 (6))
Affinity DataIC50:  5nMAssay Description:LDHA, LDHB, LDHC, MDH1 and MDH2 enzymatic assays have been described in detail previously [Dragovich, P.S. et al, Bioorg. Med. Chem. Lett. 24:3764-37...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed