BDBM199250 US9221808, 1bo::US9221808, 1bo-HCl::US9221808, 1bo-Mes
SMILES Oc1cccc(CNC(=O)Nc2nc(cs2)-c2ccncc2)c1
InChI Key InChIKey=GDVRVPIXWXOKQO-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 29 hits for monomerid = 199250
TargetRho-associated protein kinase 1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute
US Patent
H. Lee Moffitt Cancer Center And Research Institute
US Patent
Affinity DataIC50: 8nMAssay Description:Attention was focused on exploring, in turn, the SAR around the phenyl ring A, branching and substitution at the benzylic position, urea linkage of 1...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
University Of Connecticut
Curated by ChEMBL
University Of Connecticut
Curated by ChEMBL
Affinity DataIC50: 6.20nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute
US Patent
H. Lee Moffitt Cancer Center And Research Institute
US Patent
Affinity DataIC50: 9nMAssay Description:Attention was focused on exploring, in turn, the SAR around the phenyl ring A, branching and substitution at the benzylic position, urea linkage of 1...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
University Of Connecticut
Curated by ChEMBL
University Of Connecticut
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Attention was focused on exploring, in turn, the SAR around the phenyl ring A, branching and substitution at the benzylic position, urea linkage of 1...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
University Of Connecticut
Curated by ChEMBL
University Of Connecticut
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Attention was focused on exploring, in turn, the SAR around the phenyl ring A, branching and substitution at the benzylic position, urea linkage of 1...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
University Of Connecticut
Curated by ChEMBL
University Of Connecticut
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Attention was focused on exploring, in turn, the SAR around the phenyl ring A, branching and substitution at the benzylic position, urea linkage of 1...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute
US Patent
H. Lee Moffitt Cancer Center And Research Institute
US Patent
Affinity DataIC50: 8nMAssay Description:Inhibition of N-terminal GST-tagged ROCK1 (1 to 535) (unknown origin) using KKRPQRRSNVF as substrate after 1 hr by Z-Lyte-based FRET assayMore data for this Ligand-Target Pair
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Moffitt Cancer Center
Curated by ChEMBL
Moffitt Cancer Center
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of MLCK1 (unknown origin)More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
University Of Connecticut
Curated by ChEMBL
University Of Connecticut
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of N-terminal GST-tagged ROCK2 (1 to 552) (unknown origin) using KKRPQRRSNVF as substrate after 1 hr by Z-Lyte-based FRET assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute
US Patent
H. Lee Moffitt Cancer Center And Research Institute
US Patent
Affinity DataIC50: 0.530nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of LIMK1 (unknown origin)More data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))
Moffitt Cancer Center
Curated by ChEMBL
Moffitt Cancer Center
Curated by ChEMBL
Affinity DataIC50: <1nMAssay Description:Inhibition of RSK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 7.80nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Moffitt Cancer Center
Curated by ChEMBL
Moffitt Cancer Center
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of SGK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4.70E+5nMAssay Description:Inhibition of CK1-alpha1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 34nMAssay Description:Inhibition of DMPK (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase MRCK alpha(Homo sapiens (Human))
Moffitt Cancer Center
Curated by ChEMBL
Moffitt Cancer Center
Curated by ChEMBL
Affinity DataIC50: 2.90nMAssay Description:Inhibition of MRCKalpha (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase N1(Homo sapiens (Human))
Moffitt Cancer Center
Curated by ChEMBL
Moffitt Cancer Center
Curated by ChEMBL
Affinity DataIC50: <1nMAssay Description:Inhibition of PKN1 (unknown origin)More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Moffitt Cancer Center
Curated by ChEMBL
Moffitt Cancer Center
Curated by ChEMBL
Affinity DataIC50: 2.20nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: <1nMAssay Description:Inhibition of Aurora-A (unknown origin)More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
University Of Connecticut
Curated by ChEMBL
University Of Connecticut
Curated by ChEMBL
Affinity DataIC50: 0.450nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: <1nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
Moffitt Cancer Center
Curated by ChEMBL
Moffitt Cancer Center
Curated by ChEMBL
Affinity DataIC50: <1nMAssay Description:Inhibition of p70S6K (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Moffitt Cancer Center
Curated by ChEMBL
Moffitt Cancer Center
Curated by ChEMBL
Affinity DataIC50: <1nMAssay Description:Inhibition of TBK1 (unknown origin)More data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
Moffitt Cancer Center
Curated by ChEMBL
Moffitt Cancer Center
Curated by ChEMBL
Affinity DataIC50: <1nMAssay Description:Inhibition of IKKepsilon (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Moffitt Cancer Center
Curated by ChEMBL
Moffitt Cancer Center
Curated by ChEMBL
Affinity DataIC50: <1nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of ACK1 (unknown origin)More data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute
US Patent
H. Lee Moffitt Cancer Center And Research Institute
US Patent
Affinity DataIC50: 15nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
H. Lee Moffitt Cancer Center And Research Institute
US Patent
H. Lee Moffitt Cancer Center And Research Institute
US Patent
Affinity DataIC50: 13nMAssay Description:Attention was focused on exploring, in turn, the SAR around the phenyl ring A, branching and substitution at the benzylic position, urea linkage of 1...More data for this Ligand-Target Pair