BDBM207990 (2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)thiazol-4-yl)indolin-1-yl)methanone (Compound 2)
SMILES CNc1nc(cs1)-c1ccc2N(CCc2c1)C(=O)c1ccccc1OCc1ccc(Cl)cc1
InChI Key InChIKey=GOAZOFMNXDONAU-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 207990
TargetSerine/threonine-protein kinase WNK1 [1-491](Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: 180nMpH: 7.5Assay Description:A mixture of fluorescein labeled OSR1 peptide substrate (Toray Research Center, Inc.) and ATP was prepared with final concentrations of 10 and 25 ...More data for this Ligand-Target Pair
3D Structure (crystal)TargetSerine/threonine-protein kinase WNK1 [1-491](Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: 150nMpH: 7.5Assay Description:A mixture of fluorescein labeled OSR1 peptide substrate (Toray Research Center, Inc.) and ATP was prepared with final concentrations of 10 and 25 ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase WNK1 [198-401](Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: 1.60E+4nMAssay Description:For hit validation, eight compound replicates were made from the original stock dilution plates. The Cybi-WellTM dispenser was used to prepare 1.5 &#...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase WNK1 [198-401](Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: >8.00E+4nMAssay Description:For hit validation, eight compound replicates were made from the original stock dilution plates. The Cybi-WellTM dispenser was used to prepare 1.5 &#...More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of human WNK1 (198 to 401 residues) using biotinylated STK3 as substrate incubated for 2 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase WNK2 [166-489](Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: 50nMpH: 7.3Assay Description:The assay utilized 5 to 10 nM of WNK1−4 protein compared to 25 nM used for mobility shift assay, enabling a more accurate comparison of selecti...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase WNK3 [1-434](Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: 377nMpH: 7.3Assay Description:The assay utilized 5 to 10 nM of WNK1−4 protein compared to 25 nM used for mobility shift assay, enabling a more accurate comparison of selecti...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase WNK4 [1-444](Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: 187nMpH: 7.3Assay Description:The assay utilized 5 to 10 nM of WNK1−4 protein compared to 25 nM used for mobility shift assay, enabling a more accurate comparison of selecti...More data for this Ligand-Target Pair
Affinity DataIC50: 420nMAssay Description:Allosteric inhibition of recombinant human N-terminal GST-tagged WNK1 catalytic domain (1 to 491 residues) expressed in baculovirus expression system...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase WNK1 [1-491](Homo sapiens (Human))
Novartis Institutes For Biomedical Research
Novartis Institutes For Biomedical Research
Affinity DataIC50: 64nMpH: 7.3Assay Description:The assay utilized 5 to 10 nM of WNK1−4 protein compared to 25 nM used for mobility shift assay, enabling a more accurate comparison of selecti...More data for this Ligand-Target Pair