BDBM209917 US9273042, 6::US9556135, 23

SMILES CC1(C)C(N)=N[C@@](C)(CS1(=O)=O)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F

InChI Key InChIKey=SQPMMXMVMZGIEG-FQEVSTJZSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 209917   

TargetBeta-secretase 1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM209917(US9273042, 6 | US9556135, 23)
Affinity DataIC50:  0.000200nMT: 2°CAssay Description:The Abeta 40 AlphaLISA Assay can be used. The HEK293 APP cells were seeded in 96 well Microtiter plates in cell culture medium (Iscove's, plus 10% (v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCathepsin D(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM209917(US9273042, 6 | US9556135, 23)
Affinity DataIC50:  6.17E+5nMpH: 3.5Assay Description:Recombinant Cat D was expressed in CHO cells. The assay buffer for CathepsinD is 0.05 M citrate pH 3.5, 10% DMSO final, 5 mM CHAPS. The Cat D enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM209917(US9273042, 6 | US9556135, 23)
Affinity DataIC50:  2.70nMAssay Description:Several animal models, including mouse, rat, dog, and monkey, may be used to screen for inhibition of beta-secretase activity in vivo following admin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent