BDBM227588 DCA

SMILES OC(=O)C(Cl)Cl

InChI Key InChIKey=JXTHNDFMNIQAHM-UHFFFAOYSA-N

Data  9 IC50

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 227588   

Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
University Of Texas Southwestern Medical Center

LigandPNGBDBM227588(DCA)
Affinity DataIC50:  1.83E+5nMpH: 7.5 T: 2°CAssay Description:To determine the IC50 for PDK inhibitors, a mixture containing 0.05-0.2 μM PDK, 6μM E1, with or without 0.5 μM of the PDC core E2/E3BP...More data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial(Homo sapiens (Human))
University Of Texas Southwestern Medical Center

LigandPNGBDBM227588(DCA)
Affinity DataIC50:  8.00E+4nMpH: 7.5 T: 2°CAssay Description:To determine the IC50 for PDK inhibitors, a mixture containing 0.05-0.2 μM PDK, 6μM E1, with or without 0.5 μM of the PDC core E2/E3BP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1,/2,/3,/4, mitochondrial(Homo sapiens (Human))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM227588(DCA)
Affinity DataIC50: >2.00E+6nMAssay Description:In vitro inhibitory activity against pyruvate dehydrogenase kinase was determinedMore data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
University Of Texas Southwestern Medical Center

LigandPNGBDBM227588(DCA)
Affinity DataIC50:  5.04E+5nMAssay Description:Inhibition of PDK2 (unknown origin) using full length His6-tagged PDHA1 as substrate after 30 mins by ELISAMore data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
University Of Texas Southwestern Medical Center

LigandPNGBDBM227588(DCA)
Affinity DataIC50:  9.00E+6nMAssay Description:Inhibition of recombinant human GST-tagged PDK2 expressed in baculovirus infected Sf9 cells using PDHA1 as substrate measured after 1 hr by ELISAMore data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial(Homo sapiens (Human))
University Of Texas Southwestern Medical Center

LigandPNGBDBM227588(DCA)
Affinity DataIC50:  7.27E+5nMAssay Description:Inhibition of PDK4 (unknown origin) using full length His6-tagged PDHA1 as substrate after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM227588(DCA)
Affinity DataIC50:  1.03E+6nMAssay Description:Agonist activity against human melanocortin receptor hMC4RMore data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM227588(DCA)
Affinity DataIC50:  5.10E+6nMAssay Description:Inhibition of recombinant human GST-tagged PDK1 expressed in baculovirus infected Sf9 cells using PDHA1 as substrate measured after 1 hr by ELISAMore data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial(Homo sapiens (Human))
East China University Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM227588(DCA)
Affinity DataIC50:  5.56E+6nMAssay Description:Inhibition of PDK3 (unknown origin) using full length His6-tagged PDHA1 as substrate after 30 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed