BDBM227637 MTH1 inhibitor, 131

SMILES C\C(CO)=C/CNc1ncnc2[nH]cnc12

InChI Key InChIKey=UZKQTCBAMSWPJD-FARCUNLSSA-N

Data  2 IC50

PDB links: 12 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 227637   

TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Riken Center For Life Science Technologies

LigandPNGBDBM227637(MTH1 inhibitor, 131)
Affinity DataIC50:  2.20E+4nMpH: 7.5Assay Description:Enzymatic reaction was initiated by adding either 8-oxo-dGTP (13.2 μm; TriLink BioTechnologies) or 2-OH-dATP (8.3 μm; Jena Bioscience) to r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxidized purine nucleoside triphosphate hydrolase(Homo sapiens (Human))
Riken Center For Life Science Technologies

LigandPNGBDBM227637(MTH1 inhibitor, 131)
Affinity DataIC50:  1.40E+4nMpH: 7.5Assay Description:Enzymatic reaction was initiated by adding either 8-oxo-dGTP (13.2 μm; TriLink BioTechnologies) or 2-OH-dATP (8.3 μm; Jena Bioscience) to r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed