BDBM22774 1,4-Benzoquinone::Benzil-related compound, 53::CHEMBL8320::benzoquinone::cid_4650::cyclohexa-2,5-diene-1,4-dione

SMILES O=C1C=CC(=O)C=C1

InChI Key InChIKey=AZQWKYJCGOJGHM-UHFFFAOYSA-N

Data  7 KI  10 IC50  1 Kd  1 Other

PDB links: 6 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 22774   

TargetAcetylcholinesterase(Homo sapiens (Human))
University Of Mississippi

LigandPNGBDBM22774(1,4-Benzoquinone | Benzil-related compound, 53 | C...)
Affinity DataKi:  955nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
University Of Mississippi

LigandPNGBDBM22774(1,4-Benzoquinone | Benzil-related compound, 53 | C...)
Affinity DataKi:  2.05E+3nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
North-West University

Curated by ChEMBL
LigandPNGBDBM22774(1,4-Benzoquinone | Benzil-related compound, 53 | C...)
Affinity DataKi:  9.62E+3nMAssay Description:Competitive inhibition of human brain mitochondria MAO-A using kynuramine as substrate by Lineweaver-Burk analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
North-West University

Curated by ChEMBL
LigandPNGBDBM22774(1,4-Benzoquinone | Benzil-related compound, 53 | C...)
Affinity DataKi:  2.03E+4nMAssay Description:Non-competitive inhibition of human brain mitochondria MAO-B using kynuramine as substrate by Lineweaver-Burk analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Oryctolagus cuniculus (rabbit))
University Of Mississippi

LigandPNGBDBM22774(1,4-Benzoquinone | Benzil-related compound, 53 | C...)
Affinity DataKi: >1.00E+5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
University Of Mississippi

LigandPNGBDBM22774(1,4-Benzoquinone | Benzil-related compound, 53 | C...)
Affinity DataKi: >1.00E+5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
University Of Mississippi

LigandPNGBDBM22774(1,4-Benzoquinone | Benzil-related compound, 53 | C...)
Affinity DataKi: >1.00E+5nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM22774(1,4-Benzoquinone | Benzil-related compound, 53 | C...)
Affinity DataIC50:  1.39E+4nMAssay Description:Inhibition of biotin-labelled p53 binding to MDM2 (25 to 109 residues) (unknown origin) by surface plasmon resonance methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
North-West University

Curated by ChEMBL
LigandPNGBDBM22774(1,4-Benzoquinone | Benzil-related compound, 53 | C...)
Affinity DataIC50:  4.82E+3nMAssay Description:Inhibition of recombinant human MAO-A expressed in baculovirus infected BTI insect cell microsomes using kynuramine as substrate after 20 mins by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
North-West University

Curated by ChEMBL
LigandPNGBDBM22774(1,4-Benzoquinone | Benzil-related compound, 53 | C...)
Affinity DataIC50:  1.02E+4nMAssay Description:Inhibition of recombinant human MAO-B expressed in baculovirus infected BTI insect cell microsomes using kynuramine as substrate after 20 mins by flu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Schistosoma mansoni)
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM22774(1,4-Benzoquinone | Benzil-related compound, 53 | C...)
Affinity DataIC50:  8.80E+3nMAssay Description:Inhibition of Schistosoma mansoni DHODH using DHO as substrate measured at 4 secs interval for 60 secs by DCIP reduction based indirect assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 6(Rattus norvegicus)
Virginia Polytechnic Institute And State University

Curated by ChEMBL
LigandPNGBDBM22774(1,4-Benzoquinone | Benzil-related compound, 53 | C...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of histidine-tagged rat recombinant MKP3 catalytic domain expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein phosphatase 1(Mus musculus)
Virginia Polytechnic Institute And State University

Curated by ChEMBL
LigandPNGBDBM22774(1,4-Benzoquinone | Benzil-related compound, 53 | C...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of histidine-tagged mouse MKP1 catalytic domain expressed in human Hela cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetM-phase inducer phosphatase 2(Homo sapiens (Human))
Virginia Polytechnic Institute And State University

Curated by ChEMBL
LigandPNGBDBM22774(1,4-Benzoquinone | Benzil-related compound, 53 | C...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of histidine-tagged human recombinant Cdc25B catalytic domain expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
RhóNe-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM22774(1,4-Benzoquinone | Benzil-related compound, 53 | C...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibitory activity of the compound against IL-1 beta converting enzyme was evaluated.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbon monoxide dehydrogenase small chain(Oligotropha carboxidovorans)
University Of California Riverside

LigandPNGBDBM22774(1,4-Benzoquinone | Benzil-related compound, 53 | C...)
Affinity DataKd:  4.76E+4nMAssay Description:Inhibition of CODH by Diphenyliodomium chloride. Inactivation of the FAD cofactor of CODH was accomplished by covalent modification of the flavin wi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA dC->dU-editing enzyme APOBEC-3G(Homo sapiens (Human))
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM22774(1,4-Benzoquinone | Benzil-related compound, 53 | C...)
Affinity DataIC50:  3.61E+4nMT: 2°CAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Universidade De S£O Paulo

Curated by ChEMBL
LigandPNGBDBM22774(1,4-Benzoquinone | Benzil-related compound, 53 | C...)
Affinity DataIC50:  3.40E+4nMAssay Description:Inhibition of human DHODH using DHO as substrate measured at 4 secs interval for 60 secs by DCIP reduction based indirect assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Bryn Mawr College

LigandPNGBDBM22774(1,4-Benzoquinone | Benzil-related compound, 53 | C...)
Affinity DatapH: 6.5 T: 2°CAssay Description:The IC50 inhibition assays were performed in a 96-well microtiter plate format using purified recombinant IDO, which was added to the substrate, L-tr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed