BDBM23164 CHEMBL190006::FTY720-phosphate, (R)-2::[(2R)-2-amino-3-hydroxy-2-[2-(4-octylphenyl)ethyl]propoxy]phosphonic acid
SMILES CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(O)(O)=O)cc1
InChI Key InChIKey=LRFKWQGGENFBFO-LJQANCHMSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 27 hits for monomerid = 23164
Affinity DataKi: 105nM ΔG°: -8.84kcal/molepH: 7.5 T: 2°CAssay Description:Ki Values were determined by competition of [32P]-S1P binding to stably transfected CHO (S1P1,2,4) or RH7777 (S1P3,5) cells expressing the indicated ...More data for this Ligand-Target Pair
Affinity DataKi: 121nM ΔG°: -8.77kcal/molepH: 7.5 T: 2°CAssay Description:Ki Values were determined by competition of [32P]-S1P binding to stably transfected CHO (S1P1,2,4) or RH7777 (S1P3,5) cells expressing the indicated ...More data for this Ligand-Target Pair
Affinity DataKi: 277nM ΔG°: -8.31kcal/molepH: 7.5 T: 2°CAssay Description:Ki Values were determined by competition of [32P]-S1P binding to stably transfected CHO (S1P1,2,4) or RH7777 (S1P3,5) cells expressing the indicated ...More data for this Ligand-Target Pair
Affinity DataKi: 586nM ΔG°: -7.90kcal/molepH: 7.5 T: 2°CAssay Description:Ki Values were determined by competition of [32P]-S1P binding to stably transfected CHO (S1P1,2,4) or RH7777 (S1P3,5) cells expressing the indicated ...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+3nM ΔG°: >-7.60kcal/molepH: 7.5 T: 2°CAssay Description:Ki Values were determined by competition of [32P]-S1P binding to stably transfected CHO (S1P1,2,4) or RH7777 (S1P3,5) cells expressing the indicated ...More data for this Ligand-Target Pair
Affinity DataEC50: 23.3nMAssay Description:Agonist activity at human S1P1 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assayMore data for this Ligand-Target Pair
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gi dependent whole cell assayMore data for this Ligand-Target Pair
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at human S1P1 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.680nMAssay Description:Activity at human recombinant S1P1 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 16.1nMAssay Description:Agonist activity at human S1P3 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayMore data for this Ligand-Target Pair
Affinity DataEC50: 137nMAssay Description:Agonist activity at human S1P4 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.99E+3nMAssay Description:Agonist activity at human S1P5 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.160nMAssay Description:Displacement of [33P]-S1P1 from human S1P1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.140nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataIC50: >2.20E+4nMAssay Description:Agonist activity at human S1P2 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 2.5nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 0.700nMAssay Description:Agonist activity at human S1P4 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 0.460nMAssay Description:Agonist activity at human S1P5 receptor expressed in CHO cells assessed as induction of [S35]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataEC50: 18.6nMAssay Description:Activity at human recombinant S1P4 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.90nMAssay Description:Activity at human recombinant S1P5 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.70nMAssay Description:Activity at human recombinant S1P3 receptor expressed in CHO cells assessed as increase in calcium release by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 80nMpH: 7.4Assay Description:Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]-GTP-gammaS as radioligandMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMpH: 7.4Assay Description:Agonism of human S1P-2 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]-GTP-gammaS as radioligandMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+4nMpH: 7.4Assay Description:Agonism of human S1P-5 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]-GTP-gammaS as radioligandMore data for this Ligand-Target Pair
Affinity DataEC50: 29nMpH: 7.4Assay Description:Agonism of human S1P-3 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]-GTP-gammaS as radioligandMore data for this Ligand-Target Pair
Affinity DataEC50: 22nMpH: 7.4Assay Description:Agonism of human S1P-1 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]-GTP-gammaS as radioligandMore data for this Ligand-Target Pair
Affinity DataEC50: >5.00E+3nMAssay Description:Agonist activity at human S1P2 receptor assessed as effect on calcium mobilization by Gq dependent whole cell assayMore data for this Ligand-Target Pair