BDBM23251 1,2,5-Thiadiazole, TDA1::4-hydroxy-1,2,5-thiadiazole-3-carboxylic acid::LDHA Inhibitor, 1

SMILES OC(=O)c1ns[nH]c1=O

InChI Key InChIKey=FVZITYNLUYJDOE-UHFFFAOYSA-N

Data  1 KI  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 23251   

TargetL-lactate dehydrogenase(Plasmodium falciparum)
University Of Bristol

LigandPNGBDBM23251(1,2,5-Thiadiazole, TDA1 | 4-hydroxy-1,2,5-thiadiaz...)
Affinity DataKi:  290nM ΔG°:  -8.91kcal/mole IC50:  140nMpH: 7.5 T: 2°CAssay Description:An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou...More data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Universita` Di Pisa

Curated by ChEMBL
LigandPNGBDBM23251(1,2,5-Thiadiazole, TDA1 | 4-hydroxy-1,2,5-thiadiaz...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human LDH-A using pyruvate as substrate and NADH as cofactor at 125 uM after 5 mins by calorimetric assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase B chain(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM23251(1,2,5-Thiadiazole, TDA1 | 4-hydroxy-1,2,5-thiadiaz...)
Affinity DataIC50:  7.80E+3nMpH: 7.5 T: 2°CAssay Description:Enzyme assay using lactate dehydrogenase A (LDHA).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase B chain(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM23251(1,2,5-Thiadiazole, TDA1 | 4-hydroxy-1,2,5-thiadiaz...)
Affinity DataIC50:  1.03E+4nMAssay Description:An LDH enzymatic assay developed for high throughput format was used. The dehydrogenase reaction was run in the lactate to pyruvate direction and cou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Universita` Di Pisa

Curated by ChEMBL
LigandPNGBDBM23251(1,2,5-Thiadiazole, TDA1 | 4-hydroxy-1,2,5-thiadiaz...)
Affinity DataIC50:  4.50E+5nMpH: 7.5 T: 2°CAssay Description:Enzyme assay using lactate dehydrogenase A (LDHA).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed