BDBM23410 2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H-chromen-4-one::CHEMBL312163::Rhamnetin

SMILES COc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O

InChI Key InChIKey=JGUZGNYPMHHYRK-UHFFFAOYSA-N

Data  7 IC50  1 Other

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 23410   

TargetAlpha-amylase 1A(Homo sapiens (Human))
Nestle Research Center

LigandPNGBDBM23410(2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H...)
Affinity DatapH: 6.0 T: 2°CAssay Description:The assay was carried out at room temperature for 10 min with salivary alpha-amylase, starch, and test compounds. The reducing sugar was determined b...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM23410(2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H...)
Affinity DataIC50:  6.16E+4nMAssay Description:IC50 was measured as concentration required to inhibit 50% of HIV-integrase cleavageMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
King'S College London

Curated by ChEMBL
LigandPNGBDBM23410(2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of human recombinant aldose reductase using D-glyceraldehyde as substrate preincubated for 10 mins before substrate addition measured for ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol polyphosphate multikinase(Homo sapiens)
National Institute Of Environmental Health Sciences

Curated by ChEMBL
LigandPNGBDBM23410(2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of human IPMK using insP3 as substrate preincubated for 15 mins followed by substrate and measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetPancreatic alpha-amylase(Sus scrofa (Pig))
Universit£

Curated by ChEMBL
LigandPNGBDBM23410(2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H...)
Affinity DataIC50:  7.39E+4nMAssay Description:Inhibition of hog pancreas alpha-amylase using starch as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetELAV-like protein 3(Homo sapiens)
University Of Pavia

Curated by ChEMBL
LigandPNGBDBM23410(2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of ELAV3 (unknown origin)-artificial ARE complex formation after 30 mins in the presence of biotin-labeled RNA probe by chemiluminescence ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInositol hexakisphosphate kinase 2(Homo sapiens)
National Institute Of Environmental Health Sciences

Curated by ChEMBL
LigandPNGBDBM23410(2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of human IP6K2 using insP6 as substrate preincubated for 15 mins followed by substrate and measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda

Curated by ChEMBL
LigandPNGBDBM23410(2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4H...)
Affinity DataIC50:  2.87E+4nMAssay Description:IC50 was measured as concentration required to inhibit 50% of HIV-integrase integrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed