BDBM24008 1-benzyl-5'-(4-methoxyphenyl)-5-methyl-1,2-dihydro-3'H-spiro[indole-3,2'-[1,3,4]thiadiazole]-2-one::CHEMBL401435::thiadiazole derivative, 34
SMILES COc1ccc(cc1)C1=NNC2(S1)C(=O)N(Cc1ccccc1)c1ccc(C)cc21
InChI Key InChIKey=OYDZMCCYUDYFHU-UHFFFAOYSA-N
Data 8 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 24008
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5 [262-930,L692P](Homo sapiens (Human))
Wyeth Research
Wyeth Research
Affinity DataIC50: 640nMpH: 7.5 T: 2°CAssay Description:ADAMTS-5 activity was determined using a fluorescence resonance energy transfer (FRET) assay using a QF peptide containing an aggrecanase cleavage si...More data for this Ligand-Target Pair
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Wyeth Research
Wyeth Research
Affinity DataIC50: >2.20E+4nMpH: 7.5 T: 2°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 7.5 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
Affinity DataIC50: >2.20E+4nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
TargetA disintegrin and metalloproteinase with thrombospondin motifs 4(Homo sapiens (Human))
Wyeth Research
Wyeth Research
Affinity DataIC50: >2.20E+4nMAssay Description:Inhibition of ADAMTS4More data for this Ligand-Target Pair
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
University Of Athens
Curated by ChEMBL
University Of Athens
Curated by ChEMBL
Affinity DataIC50: 640nMAssay Description:Inhibition of ADAMTS5More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
Affinity DataIC50: >2.20E+4nMpH: 7.5 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair