BDBM24466 1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquinolin-4-yl)oxy]pyridin-2-yl}-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide::Substituted Pyrazolone, 17
SMILES COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)nc3)ccnc2c1
InChI Key InChIKey=GLBZSOQDAOLMGC-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 42 hits for monomerid = 24466
Affinity DataKi: 0.5nM ΔG°: -12.6kcal/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nM ΔG°: -12.1kcal/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
Affinity DataKi: 1.20nM ΔG°: -12.0kcal/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 2nM ΔG°: -11.7kcal/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
Affinity DataKi: 2.20nM ΔG°: -11.7kcal/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
Affinity DataKi: 4.10nM ΔG°: -11.3kcal/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
Affinity DataKi: 4.5nM ΔG°: -11.3kcal/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
Affinity DataKi: 2.15E+3nMAssay Description:Inhibition of IGF1R by HTRF assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.43E+3nMAssay Description:Inhibition of VEGFR2 by HTRF assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.43E+3nMAssay Description:Inhibition of VEGFR2 by HTRF assayMore data for this Ligand-Target Pair
Affinity DataKi: 4.10E+3nM ΔG°: -7.27kcal/molepH: 7.4 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of aurora-2More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CDK5/p25More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of c-KITMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Amgen
Curated by ChEMBL
Amgen
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PKAalphaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of MSK1More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of ERK1More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of p70S6KMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Amgen
Curated by ChEMBL
Amgen
Curated by ChEMBL
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of RETMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of PKBbetaMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of PIM2More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of PIM1More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of JAK1More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of FGFRKMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PKBalphaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of IRKMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of BTKMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of AblMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of TIE2More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of SrcMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of aurora-1More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of IGF1R by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of HGF-mediated c-Met autophosphorylation in human PC3 cells after 10 mins by quantitative electrochemiluminescent immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of RON by HTRF assayMore data for this Ligand-Target Pair