BDBM249422 US10537571, Compound 141::US10912774, Compound 141::US9434697, 141::US9730931, Compound 141

SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2cc(OC)cc(OC)c2Cl)c(NC(=O)C=C)c1

InChI Key InChIKey=VIXYFBBPPGAXIS-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 249422   

TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Eisai R&D Management

US Patent
LigandPNGBDBM249422(US10537571, Compound 141 | US10912774, Compound 14...)
Affinity DataIC50:  2nMpH: 7.5 T: 2°CAssay Description:Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Eisai R&D Management

US Patent
LigandPNGBDBM249422(US10537571, Compound 141 | US10912774, Compound 14...)
Affinity DataIC50: >2.00E+4nMpH: 7.5 T: 2°CAssay Description:Compounds were profiled for FGFR inhibition activity at Reaction Biology Corporation (Malvern, Pa.) with their Kinase HotSpot assay. See, Anastassiad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Eisai R&D Management

US Patent
LigandPNGBDBM249422(US10537571, Compound 141 | US10912774, Compound 14...)
Affinity DataIC50:  2nMAssay Description:Purified, recombinant FGFR4 was pre-incubated with 10 μM compound overnight at 4° C., or for 1 hour at room temperature. Following pre-incubatio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Eisai R&D Management

US Patent
LigandPNGBDBM249422(US10537571, Compound 141 | US10912774, Compound 14...)
Affinity DataIC50: >2.00E+4nMAssay Description:Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (SEQ I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Eisai R&D Management

US Patent
LigandPNGBDBM249422(US10537571, Compound 141 | US10912774, Compound 14...)
Affinity DataIC50:  2nMAssay Description:Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) was prepared as a mixture with substrate KKKSPGEYVNIEFG (SEQ ID NO:1) (20 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Eisai R&D Management

US Patent
LigandPNGBDBM249422(US10537571, Compound 141 | US10912774, Compound 14...)
Affinity DataIC50: >2.00E+4nMAssay Description:Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) was prepared as a mixture with substrate KKKSPGEYVNIEFG (SEQ ID NO:1) (20 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Eisai R&D Management

US Patent
LigandPNGBDBM249422(US10537571, Compound 141 | US10912774, Compound 14...)
Affinity DataIC50:  2nMAssay Description:Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (SEQ I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Eisai R&D Management

US Patent
LigandPNGBDBM249422(US10537571, Compound 141 | US10912774, Compound 14...)
Affinity DataIC50: >2.00E+4nMAssay Description:Recombinant FGFR1 (2.5 nM), FGFR2 (1 nM), FGFR3 (5 nM), or FGFR4 (12 nM) (Invitrogen™) was prepared as a mixture with substrate KKKSPGEYVNIEFG (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent