BDBM254603 US10214477, Example 5::US9469597, 4::US9670136, 3 (trans)-N1-((1S,2R)-2-phenylcyclopropyl)cyclohexane-1,4-diamine
SMILES NC1CCC(CC1)N[C@@H]1C[C@H]1c1ccccc1
InChI Key InChIKey=ALHBJBCQLJZYON-PFSRBDOWSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 36 hits for monomerid = 254603
Affinity DataKi: 50nMAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...More data for this Ligand-Target Pair
TargetGlutathione S-transferase P/Lysine-specific histone demethylase 1A [158-852](Homo sapiens (Human))
Oryzon Genomics
US Patent
Oryzon Genomics
US Patent
Affinity DataKi: 50nM ΔG°: -10.4kcal/molepH: 7.4 T: 2°CAssay Description:The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...More data for this Ligand-Target Pair
Affinity DataKi: 50nMAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...More data for this Ligand-Target Pair
Affinity DataKi: 550nM ΔG°: -8.53kcal/molepH: 7.4 T: 2°CAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...More data for this Ligand-Target Pair
Affinity DataKi: >4.00E+4nM ΔG°: >-6.24kcal/molepH: 7.5 T: 2°CAssay Description:In order to monitor MAO enzymatic activities and/or their inhibition rate by inhibitor(s) of interest, a fluorescence-based (inhibitor)-screening ass...More data for this Ligand-Target Pair
Affinity DataKi: >4.00E+4nM ΔG°: >-6.24kcal/molepH: 7.5 T: 2°CAssay Description:In order to monitor MAO enzymatic activities and/or their inhibition rate by inhibitor(s) of interest, a fluorescence-based (inhibitor)-screening ass...More data for this Ligand-Target Pair
Affinity DataKi: >4.00E+4nMAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...More data for this Ligand-Target Pair
Affinity DataKi: >4.00E+4nMAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...More data for this Ligand-Target Pair
Affinity DataKi: >4.00E+4nMAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...More data for this Ligand-Target Pair
Affinity DataKi: >4.00E+4nMAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...More data for this Ligand-Target Pair
Affinity DataKi: >4.00E+4nMAssay Description:Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...More data for this Ligand-Target Pair
Affinity DataKi: >4.00E+4nMAssay Description:Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...More data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A/REST corepressor 1(Homo sapiens (Human))
European Institute Of Oncology
Curated by ChEMBL
European Institute Of Oncology
Curated by ChEMBL
Affinity DataIC50: 0.600nMAssay Description:Inhibition of recombinant human KDM1A/CoREST complex expressed in Escherichia coli using biotinylated H3K4me1 peptide as substrate preincubated for 2...More data for this Ligand-Target Pair
TargetGlutathione S-transferase P/Lysine-specific histone demethylase 1A [158-852](Homo sapiens (Human))
Oryzon Genomics
US Patent
Oryzon Genomics
US Patent
Affinity DataIC50: 33nMpH: 7.4 T: 2°CAssay Description:The compounds of the invention can be tested for their ability to inhibit LSD1. The ability of the compounds of the invention to inhibit LSD1 can be ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.83E+4nMAssay Description:Inhibition of recombinant human MAOA incubated for 15 mins measured after 30 mins by luminescence-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human MAOB incubated for 15 mins measured after 30 mins by luminescence-Glo assayMore data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 2(Homo sapiens (Human))
East China Normal University
Curated by ChEMBL
East China Normal University
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human full length LSD2 using biotin-labeled H3K4me2 (1 to 24 residues) as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataEC50: >20nMAssay Description:Antagonism of Muscarinic M2 receptors as displacement of concentration response curve of carbachol on isolated guinea-pig left atriaMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 7.5 T: 2°CAssay Description:In order to monitor MAO enzymatic activities and/or their inhibition rate by inhibitor(s) of interest, a fluorescence-based (inhibitor)-screening ass...More data for this Ligand-Target Pair
Affinity DataEC50: 0.950nMAssay Description:Inhibition of LSD1 in human MV-4-11 cells assessed as increase in CD86 mRNA expression after 10 days by SYBR Green dye-bsed RT-qPCR analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.140nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...More data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant MAO-B expressed in baculovirus infected insect cells by luminescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 292nMpH: 7.4 T: 2°CAssay Description:Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMpH: 7.5 T: 2°CAssay Description:In order to monitor MAO enzymatic activities and/or their inhibition rate by inhibitor(s) of interest, a fluorescence-based (inhibitor)-screening ass...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant N-terminal His/GST-tagged LSD1 (172 to 852 residues) expressed in baculovirus infected insect cells using biotin-labe...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant MAO-A expressed in baculovirus infected insect cells by luminescence assayMore data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 2(Homo sapiens (Human))
East China Normal University
Curated by ChEMBL
East China Normal University
Curated by ChEMBL
Affinity DataIC50: 4.34E+4nMAssay Description:Inhibition of KDM1B (unknown origin)More data for this Ligand-Target Pair