BDBM2582 3,4-bis(1H-indol-3-yl)-1-methyl-2,5-dihydro-1H-pyrrole-2,5-dione::Bisindolylmaleimide deriv. 4::CHEMBL291725

SMILES CN1C(=O)C(=C(C1=O)c1c[nH]c2ccccc12)c1c[nH]c2ccccc12

InChI Key InChIKey=SWAWYMIKGOHZMR-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 2582   

TargetProtein kinase C beta type(Rattus norvegicus (rat))
Roche Products

LigandPNGBDBM2582(3,4-bis(1H-indol-3-yl)-1-methyl-2,5-dihydro-1H-pyr...)
Affinity DataIC50: >1.00E+5nMpH: 7.5 T: 2°CAssay Description:The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
Laboratoires Glaxo

LigandPNGBDBM2582(3,4-bis(1H-indol-3-yl)-1-methyl-2,5-dihydro-1H-pyr...)
Affinity DataIC50: >5.00E+4nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM2582(3,4-bis(1H-indol-3-yl)-1-methyl-2,5-dihydro-1H-pyr...)
Affinity DataIC50:  1.57E+4nMAssay Description:Inhibition of human SIRT1 by radioactive deacetylase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM2582(3,4-bis(1H-indol-3-yl)-1-methyl-2,5-dihydro-1H-pyr...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human SIRT1 by fluorescent deacetylase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM2582(3,4-bis(1H-indol-3-yl)-1-methyl-2,5-dihydro-1H-pyr...)
Affinity DataIC50:  3.30E+4nMAssay Description:Inhibition of human recombinant SIRT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM2582(3,4-bis(1H-indol-3-yl)-1-methyl-2,5-dihydro-1H-pyr...)
Affinity DataIC50:  3.30E+4nMAssay Description:Inhibition of human recombinant SIRT2 by fluorescent deacetylase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM2582(3,4-bis(1H-indol-3-yl)-1-methyl-2,5-dihydro-1H-pyr...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human SIRT1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM2582(3,4-bis(1H-indol-3-yl)-1-methyl-2,5-dihydro-1H-pyr...)
Affinity DataIC50:  2.41E+4nMAssay Description:Inhibition of human recombinant SIRT2 by radioactive deacetylase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed