BDBM2605 (Arylindolyl)maleimide deriv. 27::3-(1-methyl-1H-indol-3-yl)-4-{1-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl}-2,5-dihydro-1H-pyrrole-2,5-dione

SMILES Cn1cc(C2=C(C(=O)NC2=O)c2cn(C)c3ncccc23)c2ccccc12

InChI Key InChIKey=XGISVNPAZQTTIQ-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 2605   

TargetProtein kinase C beta type(Rattus norvegicus (rat))
Roche Products

LigandPNGBDBM2605((Arylindolyl)maleimide deriv. 27 | 3-(1-methyl-1H-...)
Affinity DataIC50:  2.90E+3nMAssay Description:The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(RAT)
University College Cork

Curated by ChEMBL
LigandPNGBDBM2605((Arylindolyl)maleimide deriv. 27 | 3-(1-methyl-1H-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant rat DYRK1A kinase domain expressed in bacteria using KKISGRLSPIMTEQ as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase haspin(Homo sapiens (Human))
University College Cork

Curated by ChEMBL
LigandPNGBDBM2605((Arylindolyl)maleimide deriv. 27 | 3-(1-methyl-1H-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human haspin kinase domain expressed in bacteria using histone H3 (1 to 21 residues) peptide as substrate in presence of [g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
University College Cork

Curated by ChEMBL
LigandPNGBDBM2605((Arylindolyl)maleimide deriv. 27 | 3-(1-methyl-1H-...)
Affinity DataIC50:  800nMAssay Description:Inhibition of recombinant full length human CDK5/p25 expressed in bacteria using histone H1 as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
University College Cork

Curated by ChEMBL
LigandPNGBDBM2605((Arylindolyl)maleimide deriv. 27 | 3-(1-methyl-1H-...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of recombinant full length human PIM1 expressed in bacteria using histone H1 as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-interacting serine/threonine-protein kinase 3(Homo sapiens (Human))
University College Cork

Curated by ChEMBL
LigandPNGBDBM2605((Arylindolyl)maleimide deriv. 27 | 3-(1-methyl-1H-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant full length human RIPK3 expressed in baculovirus infected Sf9 insect cells using MBP as substrate in presence of [gamma-33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta/[Tau protein] kinase(Sus scrofa)
University College Cork

Curated by ChEMBL
LigandPNGBDBM2605((Arylindolyl)maleimide deriv. 27 | 3-(1-methyl-1H-...)
Affinity DataIC50:  30nMAssay Description:Inhibition of domestic porcine brain full length GSK-3alpha/beta using GS-1 as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
University College Cork

Curated by ChEMBL
LigandPNGBDBM2605((Arylindolyl)maleimide deriv. 27 | 3-(1-methyl-1H-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant full length human aurora B expressed in baculovirus infected Sf9 insect cells using MBP as substrate in presence of [gamma-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
University College Cork

Curated by ChEMBL
LigandPNGBDBM2605((Arylindolyl)maleimide deriv. 27 | 3-(1-methyl-1H-...)
Affinity DataIC50:  80nMAssay Description:Inhibition of recombinant full length human CDK9/cyclin T expressed in baculovirus infected Sf9 insect cells using YSPTSPSYSPTSPSYSPTSPSKKKK as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
University College Cork

Curated by ChEMBL
LigandPNGBDBM2605((Arylindolyl)maleimide deriv. 27 | 3-(1-methyl-1H-...)
Affinity DataIC50:  100nMAssay Description:Inhibition of full length human CDK2/cyclin A using histone H1 as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed