BDBM26105 6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine::AEE788
SMILES CCN1CCN(Cc2ccc(cc2)-c2cc3c(N[C@H](C)c4ccccc4)ncnc3[nH]2)CC1
InChI Key InChIKey=OONFNUWBHFSNBT-HXUWFJFHSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 13 hits for monomerid = 26105
Affinity DataKd: 10.9nMpH: 7.4 T: 2°CAssay Description:The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro...More data for this Ligand-Target Pair
Affinity DataKd: 11.3nMpH: 7.4 T: 2°CAssay Description:The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro...More data for this Ligand-Target Pair
Affinity DataKd: 1.70nMpH: 7.4 T: 2°CAssay Description:The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro...More data for this Ligand-Target Pair
Affinity DataKd: 5.30nMpH: 7.4 T: 2°CAssay Description:The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro...More data for this Ligand-Target Pair
Affinity DataKd: 27.6nMpH: 7.4 T: 2°CAssay Description:The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro...More data for this Ligand-Target Pair
Affinity DataKd: 1.10nMpH: 7.4 T: 2°CAssay Description:The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
Frederick National Laboratory For Cancer Research
Curated by ChEMBL
Frederick National Laboratory For Cancer Research
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of Yes1 (unknown origin) assessed as kinase-dependent enzymatic production of ADP from ATP using coupled luminescence-based reaction by AD...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
National Tsing Hua University
Curated by ChEMBL
National Tsing Hua University
Curated by ChEMBL
Affinity DataIC50: 740nMAssay Description:Inhibition of RET kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of EGFR by Z-LYTE assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
University Of Genoa
Curated by ChEMBL
University Of Genoa
Curated by ChEMBL
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
University Of Genoa
Curated by ChEMBL
University Of Genoa
Curated by ChEMBL
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))
Frederick National Laboratory For Cancer Research
Curated by ChEMBL
Frederick National Laboratory For Cancer Research
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of Yes1 (unknown origin) by [gamma-33P]-ATP radiolabeled enzyme activity assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [696-1022,T790M,L858R](Homo sapiens (Human))
Harvard Medical School
Harvard Medical School
Affinity DataKd: 18.6nMpH: 7.4 T: 2°CAssay Description:The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro...More data for this Ligand-Target Pair