BDBM26282 2-{3-[(7-{3-[4-(hydroxymethyl)piperidin-1-yl]propoxy}-6-methoxyquinazolin-4-yl)amino]-1H-pyrazol-5-yl}-N-(3-methoxyphenyl)acetamide::pyrazoloquinazoline deriv., 16

SMILES COc1cccc(NC(=O)Cc2cc(Nc3ncnc4cc(OCCCN5CCC(CO)CC5)c(OC)cc34)[nH]n2)c1

InChI Key InChIKey=SJJYWHYLVWAUQL-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 26282   

TargetAurora kinase B(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM26282(2-{3-[(7-{3-[4-(hydroxymethyl)piperidin-1-yl]propo...)
Affinity DataKi:  9nM ΔG°:  -10.9kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
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TargetAurora kinase A(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM26282(2-{3-[(7-{3-[4-(hydroxymethyl)piperidin-1-yl]propo...)
Affinity DataKi:  1.90E+3nM ΔG°:  -7.80kcal/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells was incubated at room temperature with substrate, and test compounds in the ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed