BDBM263716 6-(2,4-dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid::US9714221, Example 51

SMILES OC(=O)c1ccc2c(CCCC(c3ccc(Cl)cc3Cl)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1

InChI Key InChIKey=KISZAGQTIXIVAR-VWLOTQADSA-N

Data  6 IC50  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 263716   

TargetEstrogen receptor(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263716(6-(2,4-dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropy...)
Affinity DataIC50:  15nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
TargetEstrogen receptor [D538G](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263716(6-(2,4-dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropy...)
Affinity DataIC50:  389nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
TargetEstrogen receptor [Y537S](Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263716(6-(2,4-dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropy...)
Affinity DataIC50:  221nMpH: 7.4 T: 2°CAssay Description:It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263716(6-(2,4-dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropy...)
Affinity DataIC50:  17nMAssay Description:Antagonist activity at ERalpha D538G mutant degradation in human SK-BR-3 cells incubated for 24 hrs in presence of beta-estradiol by luciferase gene ...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263716(6-(2,4-dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropy...)
Affinity DataEC50:  1.20nMAssay Description:Induction of ERalpha degradation in human MCF7 cells incubated for 24 hrs by Western blot analysisMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Shanghai Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM263716(6-(2,4-dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropy...)
Affinity DataIC50:  8.60nMAssay Description:Antagonist activity at ERbeta expressed in HEK293/Gal4 cells incubated for 24 hrs in presence of di-arylpropionitrile by luciferase reporter gene ass...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEstrogen receptor(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263716(6-(2,4-dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropy...)
Affinity DataIC50:  58nMAssay Description:Antagonist activity at ERalpha Y537S mutant degradation in human SK-BR-3 cells incubated for 24 hrs in presence of beta-estradiol by luciferase gene ...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Sanofi

US Patent
LigandPNGBDBM263716(6-(2,4-dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropy...)
Affinity DataEC50:  0.200nMAssay Description:Induction of ERalpha degradation in human MCF7 cells incubated for 4 hrs by Alexafluor-488 conjugate anti-rabbit antibody/Syto-64 staining based immu...More data for this Ligand-Target Pair