BDBM26664 7-Hydroxy-flavone, 5a::7-Hydroxyflavone, 11::7-hydroxy-2-phenyl-4H-chromen-4-one::7-hydroxyflavone::CHEMBL276915
SMILES Oc1ccc2c(c1)oc(cc2=O)-c1ccccc1
InChI Key InChIKey=MQGPSCMMNJKMHQ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 42 hits for monomerid = 26664
Affinity DataKi: 2.24E+3nMAssay Description:Inhibition of cytosolic human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 2.32E+3nMAssay Description:Inhibition of cytosolic human carbonic anhydrase 2 preincubated for 12 hrs by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
National Institute Of Diabetes
Curated by ChEMBL
National Institute Of Diabetes
Curated by ChEMBL
Affinity DataKi: 2.68E+3nMAssay Description:Affinity at Adenosine A2A receptor in rat striatal membranes by [3H]- CGS 21680 displacement.More data for this Ligand-Target Pair
TargetAdenosine receptor A2a(Rattus norvegicus (rat))
National Institute Of Diabetes
Curated by ChEMBL
National Institute Of Diabetes
Curated by ChEMBL
Affinity DataKi: 2.69E+3nMAssay Description:Ability to displace [3H]-CGS- 21680 binding from adenosine A2A receptor.Checked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 3.02E+3nMAssay Description:Ability to displace [3H]N6-phenylisopropyladenosine binding from adenosine A1 receptor.Checked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 3.03E+3nMAssay Description:Displacement of specific [3H]-PIA binding from adenosine A1 receptor in rat brain membranes.More data for this Ligand-Target Pair
Affinity DataKi: 3.37E+3nMAssay Description:Inhibition of cytosolic human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.43E+3nMAssay Description:Inhibition of cytosolic human carbonic anhydrase 1 preincubated for 12 hrs by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.53E+3nMAssay Description:Binding affinity to PKM2 (unknown origin) assessed as oxidation of beta-NADH by spectrophotometry based LDH coupled assayMore data for this Ligand-Target Pair
Affinity DataKi: 4.85E+3nMAssay Description:Inhibition of transmembrane tumor-associated human carbonic anhydrase 9 preincubated for 12 hrs by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 4.92E+3nMAssay Description:Inhibition of transmembrane tumor-associated human carbonic anhydrase 9 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 8.40E+3nMAssay Description:Inhibition of transmembrane tumor-associated human carbonic anhydrase 12 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 8.51E+3nMAssay Description:Inhibition of transmembrane tumor-associated human carbonic anhydrase 12 preincubated for 12 hrs by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Target3-hydroxyacyl-[acyl-carrier-protein] dehydratase(Plasmodium falciparum)
University Of Zurich
Curated by ChEMBL
University Of Zurich
Curated by ChEMBL
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of FabZMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of equine serum BuChE using S-butyrylcholinesterase iodide as substrate preincubated for 6 mins followed by substrate addition by Ellmans ...More data for this Ligand-Target Pair
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: 8.50E+4nMAssay Description:Inhibition of electric eel AChE using acetylthiocholine iodide as substrate preincubated for 6 mins followed by substrate addition by Ellmans methodMore data for this Ligand-Target Pair
Affinity DataKd: 3.47E+4nMAssay Description:Binding affinity to ABCB1 nucleotide binding domain 2More data for this Ligand-Target Pair
Affinity DataIC50: 30.5nMAssay Description:Inhibition of human placental microsome CYP19More data for this Ligand-Target Pair
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
University Of Innsbruck
Curated by ChEMBL
University Of Innsbruck
Curated by ChEMBL
Affinity DataIC50: 5.25E+3nMAssay Description:Inhibition of human recombinant 17beta-HSD1 expressed in HEK293 cell lysate assessed as conversion of radiolabeled estrone to estradiolMore data for this Ligand-Target Pair
Target17-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
University Of Innsbruck
Curated by ChEMBL
University Of Innsbruck
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human recombinant 17beta-HSD2 expressed in HEK293 cell lysate assessed as conversion of radiolabeled estrone to estradiolMore data for this Ligand-Target Pair
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: >4.27E+4nMAssay Description:Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881)More data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of human CYP1B1 expressed in Escherichia coli DH5alpha coexpressing human NADPH P450 reductase using 7-ethoxyresorufin as substrate in pre...More data for this Ligand-Target Pair
Target17-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
University Of Innsbruck
Curated by ChEMBL
University Of Innsbruck
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human 17beta-HSD2 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estradiol and NAD+ by scintillation countin...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
University Of Hradec Kralove
Curated by ChEMBL
University Of Hradec Kralove
Curated by ChEMBL
Affinity DataIC50: 1.23E+4nMAssay Description:Inhibition of recombinant N-terminal His6-tagged AKR1B1 (unknown origin) expressed in Escherichia coli BL21 cells using all-trans-retinal as substrat...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
University Of Hradec Kralove
Curated by ChEMBL
University Of Hradec Kralove
Curated by ChEMBL
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged AKR1B10 expressed in Escherichia coli BL21 cells using all-trans-retinal as substrate incubate...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
University Of Hradec Kralove
Curated by ChEMBL
University Of Hradec Kralove
Curated by ChEMBL
Affinity DataIC50: 1.60E+5nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged AKR1B10 expressed in Escherichia coli BL21 cells using daunorubicin as substrate incubated for...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of recombinant CYP19A1 (unknown origin) using dibenzylfluorescein as substrate incubated for 30 mins in presence of NADPH by fluorescence ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.47E+4nMAssay Description:Inhibition of ALR2 (aldose reductase) of bovine lensMore data for this Ligand-Target Pair
Affinity DataIC50: 3.71E+4nMAssay Description:Inhibition of human recombinant calmodulin assessed as inhibition of calmodulin-sensitive cAMP phosphodiesterase activation after 15 mins by spectrop...More data for this Ligand-Target Pair
Affinity DataIC50: 240nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
Universidad De Santiago De Chile
Curated by ChEMBL
Universidad De Santiago De Chile
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of 12-hLOMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Universidad De Santiago De Chile
Curated by ChEMBL
Universidad De Santiago De Chile
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of 15-hLO1More data for this Ligand-Target Pair
Target17-beta-hydroxysteroid dehydrogenase type 3(Homo sapiens (Human))
Kingston University
Curated by ChEMBL
Kingston University
Curated by ChEMBL
Affinity DataIC50: 6.70E+4nMAssay Description:Inhibition of 17beta-HSD3More data for this Ligand-Target Pair
Affinity DataIC50: 3.35E+5nMAssay Description:Inhibition of p56 lckMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX15B(Homo sapiens (Human))
Universidad De Santiago De Chile
Curated by ChEMBL
Universidad De Santiago De Chile
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of 15-hLO2More data for this Ligand-Target Pair
Affinity DataIC50: 4.52E+4nMAssay Description:The compound was tested for Inhibitory effect against ALR1 in bovine kidneysMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Loma Linda University School Of Medicine
Curated by ChEMBL
Loma Linda University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.41E+4nMAssay Description:Inhibition of PIM1 kinaseChecked by AuthorMore data for this Ligand-Target Pair
Target17-beta-hydroxysteroid dehydrogenase type 3(Homo sapiens (Human))
Kingston University
Curated by ChEMBL
Kingston University
Curated by ChEMBL
Affinity DataIC50: 9.00E+3nMpH: 7.45 T: 2°CAssay Description:Inhibition assay of human testes mcrosomal 17 beta-hydroxysteroid dehydrogenase for the reduction of androstenedione.More data for this Ligand-Target Pair
Affinity DataIC50: 2.12E+3nMAssay Description:Inhibition of recombinant PKM2 (unknown origin) Ile335, Lys367, Lys207, Thr129, Lys206, Lys207, Asn75, Hie78 residuesMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Loma Linda University School Of Medicine
Curated by ChEMBL
Loma Linda University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.40E+4nMpH: 7.0 T: 2°CAssay Description:The 96-well flat-bottomed plates were coated with recombinant GST-BAD. After the plates were blocked, the reaction buffer containing test compound an...More data for this Ligand-Target Pair
Affinity DataIC50: 1.72E+4nMT: 2°CAssay Description:The classical 3H2O assay was used to measure the effect of the flavones on aromatase activity using human placental microsomes.More data for this Ligand-Target Pair