BDBM26789 benzimidazole analog., 15::tert-butyl (3S,4S)-3-(hydroxycarbamoyl)-4-[(4-{[2-(methylsulfanyl)-1H-1,3-benzodiazol-1-yl]methyl}benzene)amido]pyrrolidine-1-carboxylate

SMILES CSc1nc2ccccc2n1Cc1ccc(cc1)C(=O)N[C@@H]1CN(C[C@@H]1C(=O)NO)C(=O)OC(C)(C)C

InChI Key InChIKey=SDNMPMDMJTYOAW-AZUAARDMSA-N

Data  4 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 26789   

TargetNeutrophil collagenase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26789(benzimidazole analog., 15 | tert-butyl (3S,4S)-3-(...)
Affinity DataKi:  1.96E+3nM ΔG°:  -7.78kcal/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26789(benzimidazole analog., 15 | tert-butyl (3S,4S)-3-(...)
Affinity DataKi:  4.08E+3nM ΔG°:  -7.35kcal/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26789(benzimidazole analog., 15 | tert-butyl (3S,4S)-3-(...)
Affinity DataKi: >4.50E+3nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26789(benzimidazole analog., 15 | tert-butyl (3S,4S)-3-(...)
Affinity DataKi: >5.03E+3nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-2(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26789(benzimidazole analog., 15 | tert-butyl (3S,4S)-3-(...)
Affinity DataIC50: >1.00E+4nMAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Sus scrofa (pig))
Bristol-Myers Squibb

LigandPNGBDBM26789(benzimidazole analog., 15 | tert-butyl (3S,4S)-3-(...)
Affinity DataIC50: <1nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM26789(benzimidazole analog., 15 | tert-butyl (3S,4S)-3-(...)
Affinity DataIC50:  540nMpH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed