BDBM269287 1-((1-(cyclopropanecarbonyl)azetidin-3-yl)methyl)-2-(2-fluoro-4-(1-methyl-1H-indazol-5-yl)phenyl)-4,4-dimethyl-1H-imidazol-5(4H)-one ::US10413545, Compound 69::US9718813, Compound 32::US9718813, Compound 69

SMILES Cn1ncc2cc(ccc12)-c1ccc(C2=NC(C)(C)C(=O)N2CC2CN(C2)C(=O)C2CC2)c(F)c1

InChI Key InChIKey=AYUJVQGEQOWLQY-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 269287   

TargetFatty acid synthase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269287(1-((1-(cyclopropanecarbonyl)azetidin-3-yl)methyl)-...)
Affinity DataIC50:  513nMpH: 7.5 T: 2°CAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFatty acid synthase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269287(1-((1-(cyclopropanecarbonyl)azetidin-3-yl)methyl)-...)
Affinity DataIC50:  110nMpH: 7.5 T: 2°CAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFatty acid synthase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269287(1-((1-(cyclopropanecarbonyl)azetidin-3-yl)methyl)-...)
Affinity DataIC50:  110nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target1,5-anhydro-D-fructose reductase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269287(1-((1-(cyclopropanecarbonyl)azetidin-3-yl)methyl)-...)
Affinity DataIC50:  214nMpH: 7.5 T: 2°CAssay Description:10 μL assay buffer (100 mM KH2PO4 pH 7.5) was added to a 384-well clear plate (costar 3702). 0.3 μL compound (at concentrations of 30 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFatty acid synthase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269287(1-((1-(cyclopropanecarbonyl)azetidin-3-yl)methyl)-...)
Affinity DataIC50:  513nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target1,5-anhydro-D-fructose reductase(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM269287(1-((1-(cyclopropanecarbonyl)azetidin-3-yl)methyl)-...)
Affinity DataIC50:  1.38E+3nMpH: 7.5 T: 2°CAssay Description:10 μL assay buffer (100 mM KH2PO4 pH 7.5) was added to a 384-well clear plate (costar 3702). 0.3 μL compound (at concentrations of 30 μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent