BDBM298386 N-(5-(tert-Butyl)-2-methoxy-3-(3-(4-((2-((3-methoxy-4-((2-(2-(2-methoxyethoxy)ethoxy)ethyl) sulfinyl)phenyl)amino)pyridin-4-yl)oxy)naphthalen-1-yl)ureido)phenyl)methanesulfonamide::US10125100, Example 11::US10392346, Example 11::US10941115, Example 11::US9751837, Example 11

SMILES COCCOCCOCCS(=O)c1ccc(Nc2cc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)ccn2)cc1OC

InChI Key InChIKey=MDUZOIRSXQZVAD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 298386   

TargetBaculoviral IAP repeat-containing protein 2 [174-256](Homo sapiens (Human))
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US Patent
LigandPNGBDBM298386(N-(5-(tert-Butyl)-2-methoxy-3-(3-(4-((2-((3-methox...)
Affinity DataIC50:  35nMAssay Description:p38 MAPKγ: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
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US Patent
LigandPNGBDBM298386(N-(5-(tert-Butyl)-2-methoxy-3-(3-(4-((2-((3-methox...)
Affinity DataIC50:  1.30E+3nMAssay Description:GSK 3α Method 2: This method follows the same steps as Method 1, but utilises a shorter period of mixing of the test compound (105 minutes inste...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
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US Patent
LigandPNGBDBM298386(N-(5-(tert-Butyl)-2-methoxy-3-(3-(4-((2-((3-methox...)
Affinity DataIC50:  318nMAssay Description:c-Src and Syk: The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
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US Patent
LigandPNGBDBM298386(N-(5-(tert-Butyl)-2-methoxy-3-(3-(4-((2-((3-methox...)
Affinity DataIC50:  76nMAssay Description:c-Src and Syk: The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent