BDBM30127 CHEMBL480988::phthalazinone, 20

SMILES COc1ccc(cc1OC)C1=NN(CCCCCBr)C(=O)C2CC=CCC12

InChI Key InChIKey=BKWWNLJWEVOUOL-UHFFFAOYSA-N

Data  7 KI  4 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 30127   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM30127(CHEMBL480988 | phthalazinone, 20)
Affinity DataKi:  2.30nM ΔG°:  -12.1kcal/molepH: 8.0 T: 2°CAssay Description:The samples were assayed in a solution composed of PDE4, [3H]cAMP/cAMP, and test compounds. To convert AMP to adenosine, snake venom was added to eac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM30127(CHEMBL480988 | phthalazinone, 20)
Affinity DataKi:  3.91E+4nMAssay Description:Displacement of [125I]RTI55 from human recombinant NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM30127(CHEMBL480988 | phthalazinone, 20)
Affinity DataKi:  3.91E+4nM EC50: >1.00E+5nMAssay Description:Binding affinity of each compound was measured by assessing the potency of inhibition of binding of radiolabeled RTI-55. Membranes were preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM30127(CHEMBL480988 | phthalazinone, 20)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [125I]RTI55 from human recombinant SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM30127(CHEMBL480988 | phthalazinone, 20)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [125I]RTI55 from human recombinant DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM30127(CHEMBL480988 | phthalazinone, 20)
Affinity DataKi: >1.00E+5nM ΔG°: >-5.40kcal/mole EC50: >1.00E+5nMpH: 7.4 T: 2°CAssay Description:Binding affinity of each compound was measured by assessing the potency of inhibition of binding of radiolabeled RTI-55. Membranes were preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM30127(CHEMBL480988 | phthalazinone, 20)
Affinity DataKi: >1.00E+5nM ΔG°: >-5.40kcal/mole EC50: >1.00E+5nMpH: 7.4 T: 2°CAssay Description:Binding affinity of each compound was measured by assessing the potency of inhibition of binding of radiolabeled RTI-55. Membranes were preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Human Biomolecular Research Institute

LigandPNGBDBM30127(CHEMBL480988 | phthalazinone, 20)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of PDE4D2 by rapid fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM30127(CHEMBL480988 | phthalazinone, 20)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of [3H]DA from human recombinant DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM30127(CHEMBL480988 | phthalazinone, 20)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of [3H]5HT from human recombinant SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Human Biomolecular Research Institute

Curated by ChEMBL
LigandPNGBDBM30127(CHEMBL480988 | phthalazinone, 20)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of [3H]NE from human recombinant NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed