BDBM3079 2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 46::6-(2,6-dichlorophenyl)-8-methyl-2-[(4-methylphenyl)amino]-7H,8H-pyrido[2,3-d]pyrimidin-7-one

SMILES Cc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1

InChI Key InChIKey=ZLNBJDSAGVBJSP-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 3079   

TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3079(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 46 | 6-(2,...)
Affinity DataIC50:  1.20E+3nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3079(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 46 | 6-(2,...)
Affinity DataIC50:  910nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3079(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 46 | 6-(2,...)
Affinity DataIC50:  50nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM3079(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 46 | 6-(2,...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human recombinant C-KitMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3079(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 46 | 6-(2,...)
Affinity DataIC50:  492nMAssay Description:Inhibition of human recombinant SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM3079(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 46 | 6-(2,...)
Affinity DataIC50:  488nMAssay Description:Inhibition of human recombinant P38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM3079(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 46 | 6-(2,...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human recombinant AblMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3079(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one 46 | 6-(2,...)
Affinity DataIC50:  480nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed