BDBM3085 6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl]amino}-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one::PD 166285 analog::PD166326

SMILES Cn1c2nc(Nc3cccc(CO)c3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O

InChI Key InChIKey=ZIQFYVPVJZEOFS-UHFFFAOYSA-N

Data  14 IC50

PDB links: 4 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 3085   

TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3085(6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl...)
Affinity DataIC50:  210nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3085(6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl...)
Affinity DataIC50:  80nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3085(6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl...)
Affinity DataIC50:  6nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3085(6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl...)
Affinity DataIC50:  90nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3085(6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl...)
Affinity DataIC50:  5.68nMpH: 7.5 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3085(6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl...)
Affinity DataIC50:  61.5nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM3085(6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl...)
Affinity DataIC50:  8nMAssay Description:Inhibition of Abl (unknown origin)More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3085(6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl...)
Affinity DataIC50: <5nMAssay Description:The kinase activity was measured by DELFIA/time-resolved fluorometry. The reaction was carried out in 96-well polypropylene plates and was terminated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3085(6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl...)
Affinity DataIC50:  82nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM3085(6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl...)
Affinity DataIC50:  140nMAssay Description:Inhibition of human recombinant P38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Csir-Indian Institute Of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM3085(6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of human recombinant AblMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM3085(6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl...)
Affinity DataIC50:  636nMAssay Description:Inhibition of human recombinant C-KitMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3085(6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl...)
Affinity DataIC50:  43nMAssay Description:Inhibition of human recombinant SrcMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3085(6-(2,6-dichlorophenyl)-2-{[3-(hydroxymethyl)phenyl...)
Affinity DataIC50:  139nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed