BDBM309315 (3R,4S)-4-(4-fluorophenyl)-N-[4-fluoro-3-(trifluoromethyl)phenyl]-1-[(1-methyl-1H-1,2,3-triazol-4-yl)sulfonyl]pyrrolidin-3-amine::US9656955, Example 840

SMILES Cn1cc(nn1)S(=O)(=O)N1C[C@H](Nc2ccc(F)c(c2)C(F)(F)F)[C@H](C1)c1ccc(F)cc1

InChI Key InChIKey=NMIDNEFOBSJZBW-QAPCUYQASA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 309315   

TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Abbvie

Curated by ChEMBL
LigandPNGBDBM309315((3R,4S)-4-(4-fluorophenyl)-N-[4-fluoro-3-(trifluor...)
Affinity DataKi:  3nMAssay Description:Inhibition of [3H]N-Methyl-SSR504734 binding to human recombinant GlyT1c expressed in CHO cell membranes incubated for 1 hr by liquid scintillation s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM309315((3R,4S)-4-(4-fluorophenyl)-N-[4-fluoro-3-(trifluor...)
Affinity DataKi: <10nMAssay Description:Radioligand binding assays using recombinant CHO cell membranes expressing human GlyT1: Radioligand binding to human GlyT1c transporter-expressing me...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent