BDBM319608 3-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)ethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one::US10174011, Example 3

SMILES Cc1nc2CCCCn2c(=O)c1CCN1CCN(CC1)c1cccc2sccc12

InChI Key InChIKey=XMFRRROSDAWYLB-UHFFFAOYSA-N

Data  8 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 319608   

Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent
LigandPNGBDBM319608(3-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)ethy...)
Affinity DataEC50:  4.57nMAssay Description:The 5-HT1A receptor agonism activity test (The agonism activity of test compounds on 5-HT1A receptor expressing human recombinant 5-HT1A receptor in ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent
LigandPNGBDBM319608(3-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)ethy...)
Affinity DataIC50:  2.61nMAssay Description:The D2 receptor antagonism activity test (The antagonism activity of test compounds on D2 receptor expressing human recombinant D2 receptor in HEK293...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent
LigandPNGBDBM319608(3-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)ethy...)
Affinity DataIC50:  15.1nMAssay Description:The 5-HT2A receptor antagonism activity test (The antagonism activity of test compounds on 5-HT2A receptor expressing human recombinant 5-HT2A recept...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistamine H1 receptor(Homo sapiens (Human))
Xinjiang Technical Institute Of Physics And Chemistry

Curated by ChEMBL
LigandPNGBDBM319608(3-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)ethy...)
Affinity DataIC50:  127nMAssay Description:Antagonist activity at histamine H1 receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Xinjiang Technical Institute Of Physics And Chemistry

Curated by ChEMBL
LigandPNGBDBM319608(3-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)ethy...)
Affinity DataIC50:  2.67E+3nMAssay Description:Inhibition of C-terminal biotin-labelled BCoR/wild-type BCL6 BTB domain (unknown origin) protein-protein interaction by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent
LigandPNGBDBM319608(3-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)ethy...)
Affinity DataIC50:  1.20nMAssay Description:Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Xinjiang Technical Institute Of Physics And Chemistry

Curated by ChEMBL
LigandPNGBDBM319608(3-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)ethy...)
Affinity DataIC50:  156nMAssay Description:Antagonist activity at adrenergic alpha1A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent
LigandPNGBDBM319608(3-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)ethy...)
Affinity DataIC50:  2.60nMAssay Description:Antagonist activity at dopamine D2 receptor (unknown origin) after 60 mins by Ultra lance cAMP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent
LigandPNGBDBM319608(3-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)ethy...)
Affinity DataEC50:  4.60nMAssay Description:Agonist activity at 5-HT1A receptor (unknown origin) after 60 mins by Ultra lance cAMP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Xinjiang Technical Institute Of Physics And Chemistry

Curated by ChEMBL
LigandPNGBDBM319608(3-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)ethy...)
Affinity DataIC50:  42nMAssay Description:Antagonist activity at 5-HT2C receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed