BDBM328408 5-fluoro-1-((4-methoxy-3-(piperazin-1-yl)phenyl)sulfonyl)-3-methyl-1H-indole::US9663498, Example 58

SMILES COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1cc(C)c2cc(F)ccc12

InChI Key InChIKey=PECOEBMXUCFJPY-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 328408   

Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM328408(5-fluoro-1-((4-methoxy-3-(piperazin-1-yl)phenyl)su...)
Affinity DataKi:  0.430nMAssay Description:Displacement of [3H]-LSD from human 5HT6R expressed in CHO cell membranes incubated for 120 mins by scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Hec Pharm Group

Curated by ChEMBL
LigandPNGBDBM328408(5-fluoro-1-((4-methoxy-3-(piperazin-1-yl)phenyl)su...)
Affinity DataIC50:  0.430nMAssay Description:The binding affinity of the compound of this invention to human 5-HT6 receptor expressed in CHO cell was evaluated by radioligand binding assay as fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent