BDBM330281 1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3- (4-((2-((4-fluorophenyl)amino)pyrimidin- 4-yl)oxy)naphthalen-1-yl)urea::US10238658, Example 23::US10813932, Example 23::US9724347, Example 23::US9993478, Example 23

SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3ccc(F)cc3)n2)c2ccccc12)C(C)(C)C

InChI Key InChIKey=VBXDFGPLWMFEQW-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 330281   

Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
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US Patent
LigandPNGBDBM330281(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Affinity DataIC50:  212nMAssay Description:The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 12(Homo sapiens (Human))
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US Patent
LigandPNGBDBM330281(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Affinity DataIC50: >1.66E+3nMAssay Description:The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
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US Patent
LigandPNGBDBM330281(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Affinity DataIC50: >1.66E+3nMAssay Description:The GSK3-α protein (500 ng/mL, 2.5 μL) was mixed with the test compound (2.5 μL at either 4 μg/mL, 0.4 μg/mL, 0.04 μg/m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
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US Patent
LigandPNGBDBM330281(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Affinity DataIC50:  212nMAssay Description:p38 MAPKα: The enzyme inhibitory activities of compounds disclosed herein were determined by FRET using synthetic peptides labelled with both do...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 12(Homo sapiens (Human))
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US Patent
LigandPNGBDBM330281(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Affinity DataIC50: >1.66E+3nMAssay Description:p38 MAPKγ: The enzyme inhibitory activities of compounds disclosed herein were determined by FRET using synthetic peptides labelled with both do...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Respivert

US Patent
LigandPNGBDBM330281(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Affinity DataIC50: >1.66E+3nMAssay Description:GSK 3α: The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Respivert

US Patent
LigandPNGBDBM330281(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Affinity DataIC50:  212nMAssay Description:The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by determining the lev...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 12(Homo sapiens (Human))
Respivert

US Patent
LigandPNGBDBM330281(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Affinity DataIC50: >1.66E+3nMAssay Description:The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashion to that descr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Respivert

US Patent
LigandPNGBDBM330281(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Affinity DataIC50: >1.66E+3nMAssay Description:The inhibitory activities of test compounds against the GSK 3α enzyme isoform (Invitrogen), were evaluated by determining the level of activatio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Respivert

US Patent
LigandPNGBDBM330281(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Affinity DataIC50:  212nMAssay Description:p38 MAPKα: The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), were evaluated indirectly by det...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 12(Homo sapiens (Human))
Respivert

US Patent
LigandPNGBDBM330281(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Affinity DataIC50: >1.66E+3nMAssay Description:p38 MAPKγ: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), were evaluated in a similar fashi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Respivert

US Patent
LigandPNGBDBM330281(1-(3-(tert-butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)- 3-...)
Affinity DataIC50: >1.66E+3nMAssay Description:GSK 3α: The enzyme inhibitory activities of compounds disclosed herein were determined by FRET using synthetic peptides labelled with both donor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent