BDBM331990 5-((2S,6R)-6-(tert-butyl)tetrahydro-2H-pyran-2-yl)-N-(2-cyclohexyl-1,5-dimethyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl)-4-methylisoxazole-3-carboxamide or 5-((2R,6S)-6-(tert-butyl)tetrahydro-2H-pyran-2-yl)-N-(2-cyclohexyl-1,5-dimethyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl)-4-methylisoxazole-3-carboxamide::US10195181, Example 16

SMILES Cc1c(noc1[C@H]1CCC[C@H](O1)C(C)(C)C)C(=O)Nc1c(C)n(C)n(C2CCCCC2)c1=O

InChI Key InChIKey=VZNLGZIMSONZEG-MOPGFXCFSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 331990   

TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM331990(5-((2S,6R)-6-(tert-butyl)tetrahydro-2H-pyran-2-yl)...)
Affinity DataIC50:  37nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent