BDBM335456 (3R,6S)-5-amino-3-(5-((7- bromopyrido[3,2-d]pyrimidin- 4-yl)amino)-2-fluorophenyl)-6- cyclopropyl-3,6-dimethyl-3,6- dihydro-2H-1,4-thiazine 1,1- dioxide::US9732088, Example 15
SMILES C[C@]1(CS(=O)(=O)[C@@](C)(C2CC2)C(N)=N1)c1cc(Nc2ncnc3cc(Br)cnc23)ccc1F
InChI Key InChIKey=PQVUIOFLWIGLEN-VXKWHMMOSA-N
Data 3 KI
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 335456
Affinity DataKi: 0.730nMAssay Description:The compounds of the invention were determined to be potent inhibitors of BACE-2 using the following assay. Inhibitor IC50s at purified human autoBAC...More data for this Ligand-Target Pair
Affinity DataKi: 1.80nMAssay Description:The compounds of the invention were determined to be potent inhibitors of BACE-1 using the following assay.The following reagents were used in this a...More data for this Ligand-Target Pair
Affinity DataKi: 321nMAssay Description:The following reagents were used in this assay: Na+-Acetate pH 5.0; 1% Brij-35; Dimethyl Sulfoxide (DMSO); Purified human Cathepsin-D (>95% pure); As...More data for this Ligand-Target Pair