BDBM33703 2-(2-Nitro-phenyl)-benzo[d][1,3]oxazin-4-one::2-(2-Nitrophenyl)-4H-3,1-benzoxazin-4-one (9)::2-(2-nitrophenyl)-3,1-benzoxazin-4-one::MLS000551096::SMR000174492::US11584714, Compound 14::cid_347675

SMILES [O-][N+](=O)c1ccccc1-c1nc2ccccc2c(=O)o1

InChI Key InChIKey=DWCFIKGNUJGZBZ-UHFFFAOYSA-N

Data  3 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 33703   

TargetMannan-binding lectin serine protease 2(Homo sapiens)
Omeros

US Patent
LigandPNGBDBM33703(2-(2-Nitro-phenyl)-benzo[d][1,3]oxazin-4-one | 2-(...)
Affinity DataKi: <1.00E+3nMAssay Description:The assay was run at room temperature in an assay buffer containing 20 mM Hepes, pH 7.4, 140 mM NaCl and 0.1% Tween 20. Assay parameters were adjuste...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProthrombin(Homo sapiens (Human))
Omeros

US Patent
LigandPNGBDBM33703(2-(2-Nitro-phenyl)-benzo[d][1,3]oxazin-4-one | 2-(...)
Affinity DataKi: <1.00E+3nMAssay Description:The thrombin assay utilizes a fluorogenic peptide substrate (Boc-VPR-AMC (R&D Systems) and was run at room temperature in an assay buffer containing ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetChymotrypsinogen A(Bos taurus (bovine))
University Of Karachi

LigandPNGBDBM33703(2-(2-Nitro-phenyl)-benzo[d][1,3]oxazin-4-one | 2-(...)
Affinity DataKi:  2.24E+4nMAssay Description:The change in optical density per minute (OD/min) was obtained by incorporating various concentrations of compounds over a range of substrate (SPpNA)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetComplement C1r subcomponent(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM33703(2-(2-Nitro-phenyl)-benzo[d][1,3]oxazin-4-one | 2-(...)
Affinity DataIC50: >6.25E+4nMAssay Description:Compound was evaluated for inhibitory activity against C1r serine protease .More data for this Ligand-Target Pair
In DepthDetails Article
TargetComplement C1r subcomponent(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM33703(2-(2-Nitro-phenyl)-benzo[d][1,3]oxazin-4-one | 2-(...)
Affinity DataIC50:  1.50E+4nMAssay Description:Compound was evaluated for inhibitory activity against C1r serine protease in assay 1More data for this Ligand-Target Pair
In DepthDetails Article
TargetChymotrypsinogen A(Bos taurus (bovine))
University Of Karachi

LigandPNGBDBM33703(2-(2-Nitro-phenyl)-benzo[d][1,3]oxazin-4-one | 2-(...)
Affinity DataIC50:  2.38E+4nMpH: 7.6Assay Description:The α-chymotrypsin inhibition activity was evaluated in 50 mM Tris-HCl buffer pH 7.6 with 10 mM CaCl2. α-Chymotrypsin (bovine pancreas) at ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XII(Homo sapiens (Human))
Pcmd

Curated by PubChem BioAssay
LigandPNGBDBM33703(2-(2-Nitro-phenyl)-benzo[d][1,3]oxazin-4-one | 2-(...)
Affinity DataIC50:  1.28E+4nMAssay Description:Molecular Library Screening Center Network (MLSCN) Penn Center for Molecular Discovery (PCMD) Assay Provider: Scott L. Diamond, University of Pennsy...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetProthrombin(Homo sapiens (Human))
Omeros

US Patent
LigandPNGBDBM33703(2-(2-Nitro-phenyl)-benzo[d][1,3]oxazin-4-one | 2-(...)
Affinity DataIC50:  116nMpH: 7.5 T: 2°CAssay Description:HTS was performed using 217,350 compounds of the MLSCN library individually plated into 10ul 1536 compound plates at a concentration of 2.5 mM each, ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetComplement C1r subcomponent(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM33703(2-(2-Nitro-phenyl)-benzo[d][1,3]oxazin-4-one | 2-(...)
Affinity DataIC50:  3.63E+4nMAssay Description:Inhibition of C1r serine proteaseMore data for this Ligand-Target Pair
In DepthDetails Article