BDBM365083 (R)-9-(3-fluorobenzyl)-6- methyl-4-(2-((1-methyl-1H- pyrazol-5- yl)amino)pyrimidin-4-yl)-8,9- dihydro-1,2,2a1,6,8- pentaazabenzo[cd]azulen- 7(6H)-one::US10278975, Compound I-39::US10517878, Compound I-39::US10842799, I-39::US11376260, Example I-39::US9867833, Compound I-39

SMILES CN1c2cc(cc3nnc([C@@H](Cc4cccc(F)c4)NC1=O)n23)-c1ccnc(Nc2ccnn2C)n1

InChI Key InChIKey=CXCRHETYYPKAES-GOSISDBHSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 365083   

TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365083((R)-9-(3-fluorobenzyl)-6- methyl-4-(2-((1-methyl-1...)
Affinity DataIC50:  0.215nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365083((R)-9-(3-fluorobenzyl)-6- methyl-4-(2-((1-methyl-1...)
Affinity DataIC50:  0.215nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 6(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365083((R)-9-(3-fluorobenzyl)-6- methyl-4-(2-((1-methyl-1...)
Affinity DataIC50:  0.215nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365083((R)-9-(3-fluorobenzyl)-6- methyl-4-(2-((1-methyl-1...)
Affinity DataIC50:  0.215nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365083((R)-9-(3-fluorobenzyl)-6- methyl-4-(2-((1-methyl-1...)
Affinity DataIC50:  0.215nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent