BDBM365160 (S)-9-(3-chlorobenzyl)-6- methyl-4-(2-((1-methyl-1H- pyrazol-5- yl)amino)pyrimidin-4-yl)-8,9- dihydro-1,2,2a1,6- tetraazabenzo[cd]azulen- 7(6H)-one::US10517878, Compound I-80::US10842799, I-80::US9867833, Compound I-80

SMILES CN1c2cc(cc3nnc([C@@H](Cc4cccc(Cl)c4)CC1=O)n23)-c1ccnc(Nc2ccnn2C)n1

InChI Key InChIKey=ITPJSEMUDAQSMQ-KRWDZBQOSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 365160   

TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365160((S)-9-(3-chlorobenzyl)-6- methyl-4-(2-((1-methyl-1...)
Affinity DataIC50: <0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365160((S)-9-(3-chlorobenzyl)-6- methyl-4-(2-((1-methyl-1...)
Affinity DataIC50: <0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365160((S)-9-(3-chlorobenzyl)-6- methyl-4-(2-((1-methyl-1...)
Affinity DataIC50: <0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent