BDBM365192 3-(3-chlorobenzyl)-5-methyl- 7-(2-((1-methyl-1H-pyrazol- 5-yl)amino)pyrimidin-4-yl)- 3H-1,2,2a1,3,5- pentaazaacenaphthylen- 4(5H)-one::US10517878, Compound I-100::US10842799, I-100::US9867833, Compound I-100

SMILES Cn1nccc1Nc1nccc(n1)-c1cc2nnc3n(Cc4cccc(Cl)c4)c(=O)n(C)c(c1)n23

InChI Key InChIKey=FZMHYWBMXOIUCM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 365192   

TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365192(3-(3-chlorobenzyl)-5-methyl- 7-(2-((1-methyl-1H-py...)
Affinity DataIC50: <0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365192(3-(3-chlorobenzyl)-5-methyl- 7-(2-((1-methyl-1H-py...)
Affinity DataIC50: <0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365192(3-(3-chlorobenzyl)-5-methyl- 7-(2-((1-methyl-1H-py...)
Affinity DataIC50: <0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent