BDBM365211 4-(9-((4-chloro-1H-pyrazol-1- yl)methyl)-8,9-dihydro-7H- 6-oxa-1,2,2a1- triazabenzo[cd]azulen-4-yl)- N-(tetrahydro-2H-pyran-4- yl)pyrimidin-2-amine::US10517878, Compound I-110::US10842799, I-110::US9867833, Compound I-110(S)

SMILES Clc1cnn(CC2CCOc3cc(cc4nnc2n34)-c2ccnc(NC3CCOCC3)n2)c1

InChI Key InChIKey=VGLZDXAKJOOLLY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 365211   

TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365211(4-(9-((4-chloro-1H-pyrazol-1- yl)methyl)-8,9-dihyd...)
Affinity DataIC50:  0.140nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365211(4-(9-((4-chloro-1H-pyrazol-1- yl)methyl)-8,9-dihyd...)
Affinity DataIC50: <0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM365211(4-(9-((4-chloro-1H-pyrazol-1- yl)methyl)-8,9-dihyd...)
Affinity DataIC50: <0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent