BDBM36539 5-chloro-2-phenoxylphenol::PT52::US10071965, Compound PT52
SMILES Oc1cc(Cl)ccc1Oc1ccccc1
InChI Key InChIKey=ZVTLRRZWZYDDLD-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 36539
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
The Research Foundation For The State University Of New York
US Patent
The Research Foundation For The State University Of New York
US Patent
Affinity DataKi: 0.100nM ΔG°: -13.6kcal/molepH: 7.5 T: 2°CAssay Description:10 μM saFabI, 15 μM inhibitor, and 500 μM NADPH were preincubated overnight at room temperature followed by a 1:200 dilution into reac...More data for this Ligand-Target Pair
3D Structure (crystal)TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
The Research Foundation For The State University Of New York
US Patent
The Research Foundation For The State University Of New York
US Patent
Affinity DataKi: 0.120nMpH: 7.5Assay Description:ThermoFluor experiments were carried out in 96-well plates (Concord) using the CFX96 RealTime PCR Detection system and C1000 Thermal Cycler (BioRad).More data for this Ligand-Target Pair
Affinity DataKi: 1.90nM ΔG°: -11.9kcal/molepH: 8.0 T: 2°CAssay Description:Inhibition constant binding to E-NAD+More data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADPH] FabI(Staphylococcus aureus)
The Research Foundation For The State University Of New York
US Patent
The Research Foundation For The State University Of New York
US Patent
Affinity DataKi: 26.9nMpH: 7.5Assay Description:Kinetics were performed on a Cary 100 spectrophotometer (Varian) at 20° C. Reaction velocities were measured by monitoring the oxidation of NAD(P)H t...More data for this Ligand-Target Pair
Affinity DataKi: 308nM ΔG°: -8.88kcal/molepH: 8.0 T: 2°CAssay Description:Inhibition constant binding to E-NADHMore data for this Ligand-Target Pair