BDBM370369 US10233189, Example 75::US10787457, Example 75::US11236096, Example 75

SMILES Cc1cc(NC(=O)c2c(Cl)n(c3ncnc(N)c23)C2(C)CC2)[nH]n1

InChI Key InChIKey=RRKLCTZEISHUPD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 370369   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM370369(US10233189, Example 75 | US10787457, Example 75 | ...)
Affinity DataIC50: <0.150nMAssay Description:To measure the inhibitory activity, first, the compounds of the present invention were individually diluted with dimethyl sulfoxide (DMSO) stepwise. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM370369(US10233189, Example 75 | US10787457, Example 75 | ...)
Affinity DataIC50: <0.150nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM370369(US10233189, Example 75 | US10787457, Example 75 | ...)
Affinity DataIC50: <0.150nMAssay Description:To measure the inhibitory activity, first, the compounds of the present invention were individually diluted with dimethyl sulfoxide (DMSO) stepwise. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent