BDBM370413 US10233189, Example 32::US10787457, Example 32::US11014930, Example 32::US11236096, Example 32

SMILES Nc1ncnc2n(nc(C(=O)Nc3cc(Br)[nH]n3)c12)C1CCCCC1

InChI Key InChIKey=VTJXWOLKQGXDHG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 370413   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM370413(US10233189, Example 32 | US10787457, Example 32 | ...)
Affinity DataIC50:  1.86nMAssay Description:To measure the inhibitory activity, first, the compounds of the present invention were individually diluted with dimethyl sulfoxide (DMSO) stepwise. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM370413(US10233189, Example 32 | US10787457, Example 32 | ...)
Affinity DataIC50:  1.86nMAssay Description:Regarding the conditions for measurement of in vitro inhibitory activity of compounds against RET kinase activity, the website of AnaSpec states that...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM370413(US10233189, Example 32 | US10787457, Example 32 | ...)
Affinity DataIC50:  1.86nMAssay Description:To measure the inhibitory activity, first, the compounds of the present invention were individually diluted with dimethyl sulfoxide (DMSO) stepwise. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Taiho Pharmaceutical

US Patent
LigandPNGBDBM370413(US10233189, Example 32 | US10787457, Example 32 | ...)
Affinity DataIC50:  1.86nMAssay Description:To measure the inhibitory activity, first, the compounds of the present invention were individually diluted with dimethyl sulfoxide (DMSO) stepwise. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent