BDBM373969 (S)-2,6-difluoro-4-((1-(2-fluorobenzyl)pyrrolidin-3-yl)(methyl)amino)-3-methyl-N-(thiazol-4-yl)benzenesulfonamide formate::US10246453, Example 236::US10815229, Example 236

SMILES CN([C@H]1CCN(Cc2ccccc2F)C1)c1cc(F)c(c(F)c1C)S(=O)(=O)Nc1cscn1

InChI Key InChIKey=JMRZDHWIINGZKK-INIZCTEOSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 373969   

TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM373969((S)-2,6-difluoro-4-((1-(2-fluorobenzyl)pyrrolidin-...)
Affinity DataIC50:  67nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM373969((S)-2,6-difluoro-4-((1-(2-fluorobenzyl)pyrrolidin-...)
Affinity DataIC50: >3.00E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM373969((S)-2,6-difluoro-4-((1-(2-fluorobenzyl)pyrrolidin-...)
Affinity DataIC50:  2.43E+4nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM373969((S)-2,6-difluoro-4-((1-(2-fluorobenzyl)pyrrolidin-...)
Affinity DataIC50:  67nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM373969((S)-2,6-difluoro-4-((1-(2-fluorobenzyl)pyrrolidin-...)
Affinity DataIC50: >3.00E+4nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM373969((S)-2,6-difluoro-4-((1-(2-fluorobenzyl)pyrrolidin-...)
Affinity DataIC50:  2.43E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent