BDBM374716 10-fluoro-8-methyl-15,16-dihydro-8H-3,6- ethenoimidazo[5,1- f][1,10,4,7,8]benzodioxatriazacyclotridecin- 17(14H)-one::US10246466, Example 41::US10618912, Example 41

SMILES CC1Oc2ccc3ncc(C(=O)NCCOc4ccc(F)cc14)n3n2

InChI Key InChIKey=XYLJTJTWOPEYJR-UHFFFAOYSA-N

Data  10 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 374716   

TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Tp Therapeutics

US Patent
LigandPNGBDBM374716(10-fluoro-8-methyl-15,16-dihydro-8H-3,6- ethenoimi...)
Affinity DataKd:  6nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Tp Therapeutics

US Patent
LigandPNGBDBM374716(10-fluoro-8-methyl-15,16-dihydro-8H-3,6- ethenoimi...)
Affinity DataKd:  280nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Tp Therapeutics

US Patent
LigandPNGBDBM374716(10-fluoro-8-methyl-15,16-dihydro-8H-3,6- ethenoimi...)
Affinity DataKd:  2.60nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Tp Therapeutics

US Patent
LigandPNGBDBM374716(10-fluoro-8-methyl-15,16-dihydro-8H-3,6- ethenoimi...)
Affinity DataKd:  33nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374716(10-fluoro-8-methyl-15,16-dihydro-8H-3,6- ethenoimi...)
Affinity DataKd:  200nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Tp Therapeutics

US Patent
LigandPNGBDBM374716(10-fluoro-8-methyl-15,16-dihydro-8H-3,6- ethenoimi...)
Affinity DataKd:  6nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Tp Therapeutics

US Patent
LigandPNGBDBM374716(10-fluoro-8-methyl-15,16-dihydro-8H-3,6- ethenoimi...)
Affinity DataKd:  280nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Tp Therapeutics

US Patent
LigandPNGBDBM374716(10-fluoro-8-methyl-15,16-dihydro-8H-3,6- ethenoimi...)
Affinity DataKd:  2.60nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Tp Therapeutics

US Patent
LigandPNGBDBM374716(10-fluoro-8-methyl-15,16-dihydro-8H-3,6- ethenoimi...)
Affinity DataKd:  33nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374716(10-fluoro-8-methyl-15,16-dihydro-8H-3,6- ethenoimi...)
Affinity DataKd:  200nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent