BDBM374728 11-fluoro-13-(hydroxymethyl)-6,7,13,14- tetrahydro-1,15-ethenopyrazolo[4,3- f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)- one::US10246466, Example 98::US10618912, Example 98

SMILES OCC1Nc2ccn3ncc(C(=O)NCCOc4ccc(F)cc14)c3n2

InChI Key InChIKey=YDZVTFFLKUNUIU-UHFFFAOYSA-N

Data  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 374728   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Tp Therapeutics

US Patent
LigandPNGBDBM374728(11-fluoro-13-(hydroxymethyl)-6,7,13,14- tetrahydro...)
Affinity DataKd:  0.740nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374728(11-fluoro-13-(hydroxymethyl)-6,7,13,14- tetrahydro...)
Affinity DataKd:  14nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Tp Therapeutics

US Patent
LigandPNGBDBM374728(11-fluoro-13-(hydroxymethyl)-6,7,13,14- tetrahydro...)
Affinity DataKd:  0.740nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Turning Point Therapeutics

US Patent
LigandPNGBDBM374728(11-fluoro-13-(hydroxymethyl)-6,7,13,14- tetrahydro...)
Affinity DataKd:  14nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent