BDBM374741 US10246467, Example I-12::US10919913, # I-12

SMILES COc1cc2nn3[C@H]4[C@@H](COc3c2cc1C(O)=O)N(CC1CC1)[C@@]1([C@@H]4c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc12

InChI Key InChIKey=JURMESUCSRKLSS-OVRLWXHPSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 374741   

TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM374741(US10246467, Example I-12 | US10919913, # I-12)
Affinity DataIC50:  986nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM374741(US10246467, Example I-12 | US10919913, # I-12)
Affinity DataIC50:  986nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent