BDBM374748 US10246467, Example I-30::US10919913, # I-30

SMILES C[C@@H]1Oc2n(nc3cc(ccc23)C(O)=O)[C@@H]2[C@H]1N(CC1CC1)[C@]1([C@H]2c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc12

InChI Key InChIKey=SDVAEDVASKNSQX-ATUJTIGVSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 374748   

TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM374748(US10246467, Example I-30 | US10919913, # I-30)
Affinity DataIC50:  10nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117](Homo sapiens (Human))
Boehringer Ingelheim International

US Patent
LigandPNGBDBM374748(US10246467, Example I-30 | US10919913, # I-30)
Affinity DataIC50:  10nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent