BDBM374755 US10246467, Example I-38::US10919913, # I-38
SMILES CC(C)CN1[C@@H]2COc3n(nc4cc(ccc34)C(O)=O)[C@@H]2[C@@H](c2cccc(Cl)c2F)[C@@]11C(=O)Nc2cc(Cl)ccc12
InChI Key InChIKey=BFYPYKNJQADWEI-NFDQLLMUSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 374755
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Boehringer Ingelheim International
US Patent
Boehringer Ingelheim International
US Patent
Affinity DataIC50: 797nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
TargetCellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117](Homo sapiens (Human))
Boehringer Ingelheim International
US Patent
Boehringer Ingelheim International
US Patent
Affinity DataIC50: 797nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair