BDBM377753 5-amino-1-(1-cyanopiperidin-3-yl)- 3-{4-[4-fluoro-2- methoxyphenoxy]phenyl}-1H- pyrazole-4-carboxamide::US10266513, Example 47::US10815213, Example 47

SMILES COc1cc(F)ccc1Oc1ccc(cc1)-c1nn(C2CCCN(C2)C#N)c(N)c1C(N)=O

InChI Key InChIKey=AGIBEGVMPFMQJD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 377753   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377753(5-amino-1-(1-cyanopiperidin-3-yl)- 3-{4-[4-fluoro-...)
Affinity DataIC50:  1.60nMAssay Description:BTK: TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM377753(5-amino-1-(1-cyanopiperidin-3-yl)- 3-{4-[4-fluoro-...)
Affinity DataIC50:  1.60nMAssay Description:TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent