BDBM379986 US10829478, Compound 98::US9926281, Compound 471

SMILES CCc1cc(ccc1Cl)N1CCN(C[C@@H]1C)C(=O)CCC1(CC(O)=O)NC(=O)NC1=O

InChI Key InChIKey=GSHKFLCNIDFHJZ-JRTLGTJJSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 379986   

TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM379986(US10829478, Compound 98 | US9926281, Compound 471)
Affinity DataIC50:  852nMAssay Description:ADAMTS-5:Protocol 2: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM379986(US10829478, Compound 98 | US9926281, Compound 471)
Affinity DataIC50:  12.5nMAssay Description:TABLE X: The IC50 value for test compounds can be determined in a fluorescent based protease assay.The basis for the assay is the cleavage of the sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetA disintegrin and metalloproteinase with thrombospondin motifs 5(Homo sapiens (Human))
Galapagos

US Patent
LigandPNGBDBM379986(US10829478, Compound 98 | US9926281, Compound 471)
Affinity DataIC50: >1.00E+4nMAssay Description:TABLE IX: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID NO: 2) by human ADAMTS-5.For th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent